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- Table of Contents
RANGAP1 Antibodies
AND RANGAP1 ELISA kits, RANGAP1 Proteins
Many biological assays use antibodies to detect RANGAP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RANGAP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RANGAP1 antibodies...
Designing a Western blot for RANGAP1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RANGAP1 Western Blot GuideDesigning an IHC experiment for RANGAP1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the RANGAP1 IHC GuideRANGAP1 Infographic by Boster Bio
All RANGAP1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02771-2
100 μg/vial
Cat # A02771-2
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02771-1
100 μl/vial
Cat # M02771-1
100 μl/vial
RANGAP1 Overview
Facts about Ran GTPase-activating protein 1.
Ran GTPase-activating protein 1 (RANGAP1)
GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860).
Converts cytoplasmic GTP-bound RAN into GDP-bound RAN, which is vital for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050).Mediates dissociation of cargo from nuclear export complexes comprising XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). .
Gene Information
| Human | |
|---|---|
| Gene Name: | RANGAP1 |
| Uniprot: | P46060 |
| Entrez: | 5905 |
Family
| Belongs to: |
|---|
| RNA1 family |
Alternative Names
Fug1; KIAA1835Fug1; MGC20266; Ran GTPase activating protein 1; ran GTPase-activating protein 1; RanGAP1; SD; segregation distorter homolog (Drosophila); segregation distorter homolog; segregation distortion
Molecular Weight
Mass (kDA):
63.542 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.2 |
| Sequence: | 22; NC_000022.11 (41244779..41302369, complement) |
Tissue Specificity
Highly expressed in brain, thymus and testis.
Subcellular Localizations
Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasmic during interphase. Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602). Targeted to the nuclear pores after sumoylation (PubMed:11854305). During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602). Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305). Mitotic location also requ
Diseases
- Leukemia
- Acute Promyelocytic Leukemia
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Neurodegenerative Disorders
- Malignant Neoplasm Of Prostate
- Cell Transformation, Neoplastic
- Progeria
- Leukoencephalopathy, Progressive Multifocal
- Melanoma
- De Novo Mutation
Interacting Proteins
- SUMO1
- UBE2I
Pathways
- Transport
- Localization
- Mitosis
- Conjugation
- Nucleocytoplasmic Transport
- Cell Cycle
- Nuclear Transport
- Interphase
- Nuclear Import
- Nuclear Export
- Protein Import
- Cell Division
- Spindle Assembly
PTMs
- Sumoylation
- Ubiquitination
- Cleavage
- Phosphorylation
Research Areas
- Cellular Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RANGAP1
bosterbio.com/bosterbio-gene-info-cards/RANGAP1
References
PMID: 7878053 by Bischoff F.R., et al. Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport.
PMID: 8146159 by Bischoff F.R., et al. RanGAP1 induces GTPase activity of nuclear Ras-related Ran.