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- Table of Contents
RAPH1 Antibodies
AND RAPH1 ELISA kits, RAPH1 Proteins
Many biological assays use antibodies to detect RAPH1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAPH1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAPH1 antibodies...
Designing an IHC experiment for RAPH1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the RAPH1 IHC GuideRAPH1 Infographic by Boster Bio
All RAPH1 Products
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Specificity
Applications
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RAPH1 Overview
Facts about Ras-associated and pleckstrin homology domains-containing protein 1.
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1)
Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics.
Negatively regulates cell adhesion. .
Gene Information
| Human | |
|---|---|
| Gene Name: | RAPH1 |
| Uniprot: | Q70E73 |
| Entrez: | 65059 |
Family
| Belongs to: |
|---|
| MRL family |
Alternative Names
candidate 18; candidate 9; lamellipodin; PREL2; PREL-2; proline rich EVH1 ligand 2; Protein RMO1; Ras association (RalGDS/AF-6) and pleckstrin homology domains 1; ras-associated and pleckstrin homology domains-containing protein 1; RMO1
Molecular Weight
Mass (kDA):
135.256 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q33.2 |
| Sequence: | 2; NC_000002.12 (203433682..203535322, complement) |
Tissue Specificity
Isoform RMO1-RAPH1 is ubiquitously expressed with highest levels in brain, heart, ovary and developing embryo. Isoform RMO1 is widely expressed with highest levels in liver. Low expression in B-cells.
Subcellular Localizations
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cell projection, filopodium. Cytoplasm, cytoskeleton. Recruited to the membrane, via the PH domain, by the phosphoinositide, PI(3,4)P2. Colocalizes with ENAH/VASP at the tips of lamellipodia and filopodia. Also colocalizes with the pathogens, Vaccinia and Enteropathogenic E.coli (EPEC) at the interface between the pathogen and their actin.
Diseases
- Tissue Adhesions
- Systemic Infection
- Malignant Neoplasms
- Neoplasms
- Nervousness
- Cell Invasion
- Adenocarcinoma
- Vaccinia
- Neoplasm Metastasis
- Transfusion Reaction
- Mastitis-metritis-agalactia Syndrome
- Tumor Progression
- Malignant Neoplasm Of Breast
Interacting Proteins
- EGFR
- Sh3gl1
- SH3GL2
- SH3GL3
Pathways
- Localization
- Cell Migration
- Cell Division
- Cell Proliferation
- Cell Motility
- Locomotion
- Dendrite Development
- Keratinocyte Proliferation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAPH1
bosterbio.com/bosterbio-gene-info-cards/RAPH1
References
PMID: 11586298 by Hadano S., et al. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.
PMID: 15469845 by Krause M., et al. Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.