Ras-interacting protein 1 (RASIP1)

Required for the correct formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is vital for endothelial cell morphogenesis and blood vessel tubulogenesis.

Regulates the activity of Rho GTPases in part by recruitment ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 actions in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins.