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RNA-binding protein 15 Antibodies
AND RBM15 ELISA kits, RNA-binding protein 15 Proteins
Many biological assays use antibodies to detect RNA-binding protein 15, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNA-binding protein 15 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNA-binding protein 15 antibodies...
Designing a Western blot for RNA-binding protein 15? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RBM15 Western Blot GuideDesigning an IHC experiment for RNA-binding protein 15? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the RBM15 IHC GuideRBM15 Infographic by Boster Bio
All RBM15 Products
Product
Figures
Specificity
Applications
Price
Human, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A11484-1
100 µg/vial
Cat # A11484-1
100 µg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A04395
100 µg/vial
Cat # A04395
100 µg/vial
RBM15 Overview
Facts about RNA-binding protein 15.
RNA-binding protein 15 (RBM15)
RNA-binding protein that acts as a key regulator of N6- methyladenosine (m6A) methylation of RNAs, thereby regulating distinct procedures, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated element of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification which plays a role in the efficiency of mRNA splicing and RNA processing (By similarity).
Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518).
Gene Information
| Human | |
|---|---|
| Gene Name: | RBM15 |
| Uniprot: | Q96T37 |
| Entrez: | 64783 |
Family
| Belongs to: |
|---|
| RRM Spen family |
Alternative Names
FLJ12479; one twenty two protein; one twenty-two; One-twenty two protein 1; putative RNA-binding protein 15; RNA binding motif protein 15; RNA-binding motif protein 15; SPEN
Molecular Weight
Mass (kDA):
107.189 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p13.3 |
| Sequence: | 1; NC_000001.11 (110339323..110346681) |
Subcellular Localizations
Nucleus speckle. Nucleus, nucleoplasm. Nucleus envelope. Nucleus membrane; Peripheral membrane protein. Colocalizes at the nuclear pore with DBP5 and NXF1.
Diseases
- Acute Megakaryocytic Leukemias
- Leukemia
- Leukemogenesis
- Malignant Neoplasms
- Myeloid Leukemia
- Acute Leukemia
- Malignant Neoplasm Of Breast
- Neoplasms
- Mammary Neoplasms
- Adult Acute Myeloblastic Leukemia
- Myeloid Leukemia, Chronic
Interacting Proteins
- CALCOCO2
- CEP44
- DDX17
- LZTS2
- NAV2
Pathways
- Nuclear Export
- Transport
- Rna Interference
- Rna Transport
- Cell Growth
- Pathogenesis
- Granulocyte Differentiation
- Gland Development
- Gene Silencing
- Aging
- Mammary Gland Development
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RBM15
bosterbio.com/bosterbio-gene-info-cards/RBM15
References
PMID: 11431691 by Ma Z., et al. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.
PMID: 11344311 by Mercher T., et al. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia.