RNA-binding protein 25 (RBM25)

RNA-binding protein that functions as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression.

Modulates the proportion of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, arouses proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) choice, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L.