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- Table of Contents
Facts about Ras-related and estrogen-regulated growth inhibitor.
In cell lines overexpression leads to a decline in the rate of proliferation, colony formation and in tumorigenic potential. .
Human | |
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Gene Name: | RERG |
Uniprot: | Q96A58 |
Entrez: | 85004 |
Belongs to: |
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small GTPase superfamily |
MGC15754; RAS-like, estrogen-regulated, growth inhibitor; ras-related and estrogen-regulated growth inhibitor
Mass (kDA):
22.608 kDA
Human | |
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Location: | 12p12.3 |
Sequence: | 12; NC_000012.12 (15107783..15221417, complement) |
Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor- positive breast-derived cell lines, but not in estrogen receptor- negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis.
Cytoplasm.
PMID: 11533059 by Finlin B.S., et al. RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer.