E3 ubiquitin-protein ligase RNF220 (RNF220)

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 boosting Wnt signaling (PubMed:25266658).

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