40S ribosomal protein S3 (RPS3)

Cleaves phosphodiester bonds of DNAs containing altered foundations with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a frequent DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345).

Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase action of the base excision protein OGG1 (PubMed:15518571).