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- Table of Contents
RPS6KA1 Antibodies
AND RPS6KA1 ELISA kits, RPS6KA1 Proteins
Many biological assays use antibodies to detect RPS6KA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RPS6KA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RPS6KA1 antibodies...
Designing a Western blot for RPS6KA1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RPS6KA1 Western Blot GuideRPS6KA1 Infographic by Boster Bio
All RPS6KA1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IF, ICC, WB
$370
Cat # P01058-1
100 μl
Cat # P01058-1
100 μl
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01058-2
100 μl/vial
Cat # M01058-2
100 μl/vial
Human
IF, ICC, WB
$370
Cat # M01058T573
100 µl/vial
Cat # M01058T573
100 µl/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M01058-3
20μL, 40μL, 100μL, 200μL
Cat # M01058-3
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M01058-5
20μL, 40μL, 100μL, 200μL
Cat # M01058-5
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M01058-4
20μL, 40μL, 100μL, 200μL
Cat # M01058-4
20μL, 40μL, 100μL, 200μL
Human, Mouse
ELISA
$540
Cat # EKC2583
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2583
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2101
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2101
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2100
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2100
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2099
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2099
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$480
Cat # EKC1508
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1508
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1434
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1434
1 kit, containing one 96-well plate and all necessary reagents
RPS6KA1 Overview
Facts about Ribosomal protein S6 kinase alpha-1.
Ribosomal protein S6 kinase alpha-1 (RPS6KA1)
In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which leads to the following transcriptional activation of numerous immediate-early genes. Upon insulin- derived signal, acts indirectly on the transcription regulation of many genes by phosphorylating GSK3B at'Ser-9' and inhibiting its activity.
Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complicated. In response to insulin, phosphorylates EIF4B, improving EIF4B affinity for the EIF3 complicated and stimulating cap-dependent translation.
Gene Information
| Human | |
|---|---|
| Gene Name: | RPS6KA1 |
| Uniprot: | Q15418 |
| Entrez: | 6195 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
90kD, polypeptide 1); EC 2.7.11; EC 2.7.11.1,90 kDa ribosomal protein S6 kinase 1; HU-1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; MAPKAPL1A; p90RSK1; p90S6K; ribosomal protein S6 kinase alpha 1; ribosomal protein S6 kinase alpha-1; ribosomal protein S6 kinase, 90kD, polypeptide 1; ribosomal protein S6 kinase, 90kDa, polypeptide 1; Ribosomal S6 kinase 1; RPS6KA1; RSK; RSK1; RSK-1; RSK1p90-RSK 1; S6K-alpha 1; S6K-alpha-1
Molecular Weight
Mass (kDA):
82.723 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.11 |
| Sequence: | 1; NC_000001.11 (26529761..26575028) |
Subcellular Localizations
Nucleus. Cytoplasm.
Diseases
- Neoplasms
- Malignant Neoplasms
- Hypertrophy
- Insulin Resistance
- Obesity
- Inflammation
- Hyperplasia
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Cell Transformation, Neoplastic
- Mammary Neoplasms
- Cardiac Hypertrophy
- Insulin Sensitivity
Interacting Proteins
- AKAP8
- CDKN1B
- HSP90AB1
- MAPK1
- SCRIB
- VASP
Pathways
- Translation
- Cell Growth
- Pathogenesis
- Cell Proliferation
- Localization
- Cell Cycle
- Cell Death
- Autophagy
- Secretion
- Cell Motility
- Virulence
- Regeneration
- Neurogenesis
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
Research Areas
- MAP Kinase Signaling
- mTOR Pathway
- Phospho-Specific
- Protein Kinase
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RPS6KA1
bosterbio.com/bosterbio-gene-info-cards/RPS6KA1
References
PMID: 8141249 by Moller D.E., et al. Human rsk isoforms: cloning and characterization of tissue-specific expression.
PMID: 9687510 by Deak M., et al. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.