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- Table of Contents
Facts about Run domain Beclin-1-interacting and cysteine-rich domain-containing protein.
Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). .
Human | |
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Gene Name: | RUBCN |
Uniprot: | Q92622 |
Entrez: | 9711 |
Belongs to: |
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No superfamily |
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Mass (kDA):
108.622 kDA
Human | |
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Location: | 3q29 |
Sequence: | 3; NC_000003.12 (197668867..197749727, complement) |
Late endosome. Lysosome. Early endosome. Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.
PMID: 19270696 by Matsunaga K., et al. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.
PMID: 20826435 by Assoum M., et al. Rundataxin, a novel protein with RUN and diacylglycerol binding domains, is mutant in a new recessive ataxia.