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Scube2 Antibodies
AND Scube2 ELISA kits, Scube2 Proteins
Many biological assays use antibodies to detect Scube2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Scube2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Scube2 antibodies...
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Scube2 Infographic by Boster Bio
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Scube2 Overview
Facts about Signal peptide, CUB and EGF-like domain-containing protein 2.
Signal peptide, CUB and EGF-like domain-containing protein 2 (Scube2)
Lipid-binding protein required for SHH long-lived signaling by binding to the dually lipid-modified SHH (ShhNp) and by encouraging ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by improving the proteolytic processing (shedding) of the lipid- modified N- and C- terminal of ShhNp in the cell surface (PubMed:24522195).
Synergizes with DISP1 to cause a boost in SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved with VEGFR2-mediated angiogenesis (PubMed:27834687).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Scube2 |
| Uniprot: | Q9JJS0 |
| Entrez: | 56788 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Cegb1; CEGF1; CEGP1; FLJ16792; FLJ35234; MGC133057; Protein CEGP1; signal peptide, CUB and EGF-like domain-containing protein 2; signal peptide, CUB domain, EGF-like 2
Molecular Weight
Mass (kDA):
109.924 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 7 E3|7 57.53 cM |
| Sequence: | 7; |
Tissue Specificity
Expressed in adult heart, lung and testis.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Tumor Progression
- Carcinoma
- Nervousness
- Neoplasm Metastasis
- Monoclonal Gammapathies
- Monoclonal Gammopathy Of Undetermined Significance
- Purpura, Thrombotic Thrombocytopenic
- Tumor Angiogenesis
Pathways
- Cell Proliferation
- Transport
- Secretory Pathway
- Spinal Cord Patterning
- Organ Development
- Glycosylation
- Angiogenesis
PTMs
- Disulfide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Scube2
bosterbio.com/bosterbio-gene-info-cards/Scube2
References
PMID: 11528127 by Amid C., et al. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7.
PMID: 11287194 by Grimmond S., et al. Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development.