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- Table of Contents
SF3B3 Antibodies
AND SF3B3 ELISA kits, SF3B3 Proteins
Many biological assays use antibodies to detect SF3B3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SF3B3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SF3B3 antibodies...
Designing an IHC experiment for SF3B3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SF3B3 IHC GuideSF3B3 Infographic by Boster Bio
All SF3B3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A08240-3
100 μg/vial
Cat # A08240-3
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M08240-1
100 μl/vial
Cat # M08240-1
100 μl/vial
SF3B3 Overview
Facts about Splicing factor 3B subunit 3.
Splicing factor 3B subunit 3 (SF3B3)
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complicated, a constituent of the spliceosome (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA.
Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114).
Gene Information
| Human | |
|---|---|
| Gene Name: | SF3B3 |
| Uniprot: | Q15393 |
| Entrez: | 23450 |
Family
| Belongs to: |
|---|
| RSE1 family |
Alternative Names
KIAA0017splicing factor 3b, subunit 3, 130kD; Pre-mRNA-splicing factor SF3b 130 kDa subunit; RSE1; SAP130SAP 130; SF3B130; SF3b130pre-mRNA splicing factor SF3b, 130 kDa subunit; Spliceosome-associated protein 130; splicing factor 3B subunit 3; splicing factor 3b, subunit 3, 130kDa; STAF130
Molecular Weight
Mass (kDA):
135.577 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q22.1 |
| Sequence: | 16; NC_000016.10 (70523816..70577668) |
Subcellular Localizations
Nucleus.
Diseases
- Hereditary Diseases
- Malignant Neoplasm Of Breast
- Xeroderma
- Xeroderma Pigmentosum
- Neoplasm Invasiveness
- Invasive Breast Carcinoma
- Carcinogenesis
- Carcinoma
- Haploinsufficiency
- Xeroderma Pigmentosum Complementation Group A
- Malignant Neoplasms
Interacting Proteins
- NUDCD3
Pathways
- Dna Repair
- Chromatin Modification
- Cell Division
- Histone H3 Acetylation
- Cell Proliferation
- Translation
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SF3B3
bosterbio.com/bosterbio-gene-info-cards/SF3B3
References
PMID: 10490618 by Das B.K., et al. Characterization of a protein complex containing spliceosomal proteins saps 49,130,145 and 155.
PMID: 10882114 by Das R., et al. Functional association of U2 snRNP with the ATP-independent spliceosomal complex E.