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- Table of Contents
Alpha-sarcoglycan Antibodies
AND SGCA ELISA kits, Alpha-sarcoglycan Proteins
Many biological assays use antibodies to detect Alpha-sarcoglycan, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Alpha-sarcoglycan in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Alpha-sarcoglycan antibodies...
Designing a Western blot for Alpha-sarcoglycan? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SGCA Western Blot GuideSGCA Infographic by Boster Bio
All SGCA Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M04756
100 μl
Cat # M04756
100 μl
Human
$628
Cat # LS006442
20 µg, 100 µg
Cat # LS006442
20 µg, 100 µg
SGCA Overview
Facts about Alpha-sarcoglycan.
Alpha-sarcoglycan (SGCA)
Part of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. .
Gene Information
| Human | |
|---|---|
| Gene Name: | SGCA |
| Uniprot: | Q16586 |
| Entrez: | 6442 |
Family
| Belongs to: |
|---|
| sarcoglycan alpha/epsilon family |
Alternative Names
50-DAG; Adhalin; ADL; alphaSarcoglycan; alpha-Sarcoglycan; DAG2; DMDA2; DMDA250kD DAG; Dystroglycan-2; LGMD2D; LGMD2Dalpha (50kD dystrophin-associated glycoprotein); sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein); SCARMD1; SGCA
Molecular Weight
Mass (kDA):
42.875 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.33 |
| Sequence: | 17; NC_000017.11 (50165517..50175928) |
Tissue Specificity
Most strongly expressed in skeletal muscle. Also expressed in cardiac muscle and, at much lower levels, in lung. In the fetus, most abundant in cardiac muscle and, at lower levels, in lung. Also detected in liver and kidney. Not expressed in brain.
Subcellular Localizations
Cell membrane, sarcolemma; Single-pass type I membrane protein. Cytoplasm, cytoskeleton.
Diseases
- Muscular Dystrophy
- Dystrophy
- Muscular Dystrophies, Limb-girdle
- Sarcoglycanopathies
- Astrocytoma
- Sclerosis
- Neoplasms
- Tuberous Sclerosis
- Subependymal Giant Cell Astrocytoma
- Myopathy
- Brain Neoplasms
- Glioma
Interacting Proteins
- SGTA
Pathways
- Chemotaxis
- Pathogenesis
- Cell Proliferation
- Programmed Cell Death
- Localization
- Cell Death
- Cell Adhesion
- Aging
- Glycosylation
- Regeneration
PTMs
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SGCA
bosterbio.com/bosterbio-gene-info-cards/SGCA
References
PMID: 8069911 by Roberds S.L., et al. Missense mutations in the adhalin gene linked to autosomal recessive muscular dystrophy.
PMID: 7937874 by McNally E., et al. Human adhalin is alternatively spliced and the gene is on chromosome 17q21.