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SGK3 Antibodies
AND SGK3 ELISA kits, SGK3 Proteins
Many biological assays use antibodies to detect SGK3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SGK3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SGK3 antibodies...
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SGK3 Overview
Facts about Serine/threonine-protein kinase Sgk3.
Serine/threonine-protein kinase Sgk3 (SGK3)
Serine/threonine-protein kinase that is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.
3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density.
Gene Information
| Human | |
|---|---|
| Gene Name: | SGK3 |
| Uniprot: | Q96BR1 |
| Entrez: | 23678 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CISK; DKFZp781N0293; EC 2.7.11; EC 2.7.11.1; serine/threonine-protein kinase Sgk3; serum/glucocorticoid regulated kinase 3; serum/glucocorticoid regulated kinase family, member 3; serum/glucocorticoid regulated kinase-like; Serum/glucocorticoid-regulated kinase 3; Serum/glucocorticoid-regulated kinase-like; SGK2; SGKLcytokine-independent survival kinase
Molecular Weight
Mass (kDA):
57.108 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q13.1 |
| Sequence: | 8; NC_000008.11 (66712781..66862022) |
Tissue Specificity
Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER- positive breast tumors than ER-negative breast tumors.
Subcellular Localizations
Cytoplasmic vesicle. Early endosome. Recycling endosome. Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes.
Diseases
- Neoplasms
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Carcinoma
- Mammary Neoplasms
- Hypertensive Disease
- Kidney Diseases
- Diabetic Nephropathy
- Ischemia
- Familial Hypophosphatemia
- Cell Transformation, Neoplastic
- Sclerosis
- Adenoma
Interacting Proteins
- ITCH
Pathways
- Transport
- Cell Proliferation
- Excretion
- Localization
- Hair Follicle Development
- Amino Acid Transport
- Secretion
- Hair Follicle Morphogenesis
- Cell Growth
- Rna Interference
- Intestinal Absorption
- Glucose Homeostasis
- Anagen
PTMs
- Phosphorylation
- Carboxylation
Research Areas
- GPCR
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SGK3
bosterbio.com/bosterbio-gene-info-cards/SGK3
References
PMID: 10548550 by Kobayashi T., et al. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.
PMID: 10585774 by Dai F., et al. Cloning and mapping of a novel human Serum/Glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1.