SGPP2 Antibodies

AND SGPP2 ELISA kits, SGPP2 Proteins

Many biological assays use antibodies to detect SGPP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SGPP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SGPP2 antibodies...

We validate the specificity of these antibodies to SGPP2 by testing them on tissues known to express SGPP2 positively and negatively. Browse below to find the SGPP2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SGPP2 Infographic by Boster Bio

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Sphingosine 1 phosphate phosphatase 2 (SGPP2) (NM_152386) Human Over-expression Lysate

Human

$628
Cat # LS130367
20 µg, 100 µg

SGPP2 Overview

Facts about Sphingosine-1-phosphate phosphatase 2.

SGPP2 3D structure. Source: alphafold

Sphingosine-1-phosphate phosphatase 2 (SGPP2)

Has special phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro.

May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling.

Gene Information

Human
Gene Name:	SGPP2
Uniprot:	Q8IWX5
Entrez:	130367

Family

Belongs to:

type 2 lipid phosphate phosphatase family

Alternative Names

EC 3.1.3; EC 3.1.3.-; FLJ39004; hSPP2; sphingosine 1-phosphate phosphohydrolase 2; Sphingosine-1-phosphatase 2; sphingosine-1-phosphate phosphatase 2; Spp2; SPP2sphingosine-1-phosphate phosphotase 2; SPPase2

Molecular Weight

Mass (kDA):
44.741 kDA

Genomic Context


Human

Location:	2q36.1
Sequence:	2; NC_000002.12 (222423988..222562621)

Tissue Specificity

Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Inflammation
Inflammatory Disorder
Endometriosis, Site Unspecified
Fracture
Ovarian Diseases
Psoriasis
Malignant Neoplasms
Neoplasms
Endometrial Polyp

Osteoporosis
Esophageal Neoplasms
Dermatologic Disorders

Pathways

Endochondral Bone Growth
Cell Proliferation
Proteolysis
Localization
Mesenchymal Cell Proliferation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SGPP2

References

PMID: 12411432 by Ogawa C., et al. Identification and characterization of a novel human sphingosine-1- phosphate phosphohydrolase, hSPP2.

PMID: 27059959 by Taguchi Y., et al. Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet beta-Cell Endoplasmic Reticulum Stress and Proliferation.