SH3PXD2A Antibodies

AND SH3PXD2A ELISA kits, SH3PXD2A Proteins

Many biological assays use antibodies to detect SH3PXD2A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SH3PXD2A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SH3PXD2A antibodies...

We validate the specificity of these antibodies to SH3PXD2A by testing them on tissues known to express SH3PXD2A positively and negatively. Browse below to find the SH3PXD2A antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for SH3PXD2A? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the SH3PXD2A IHC Guide

SH3PXD2A Infographic by Boster Bio

All SH3PXD2A Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

FISH (SH3PXD2A) (NM_014631) Human Over-expression Lysate

Human

$960
Cat # LS009644
20 µg, 100 µg

Anti-SH3PXD2A antibody

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$370
Cat # A05241-1
100 μl/vial

Anti-Fish SH3PXD2A Antibody

Immunohistochemical analysis of paraffin-embedded human uterus

Human, Mouse

ELISA, IF, IHC, WB

$380
Cat # A05241
100ul

SH3PXD2A Overview

Facts about SH3 and PX domain-containing protein 2A.

SH3PXD2A 3D structure. Source: alphafold

SH3 and PX domain-containing protein 2A (SH3PXD2A)

Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides.

Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.

Gene Information

Human
Gene Name:	SH3PXD2A
Uniprot:	Q5TCZ1
Entrez:	9644

Family

Belongs to:

SH3PXD2 family

Alternative Names

adaptor protein TKS5; SH3 and PX domains 2A

Molecular Weight

Mass (kDA):
125.289 kDA

Genomic Context


Human

Location:	10q24.33
Sequence:	10; NC_000010.11 (103594027..103855406, complement)

Tissue Specificity

Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas.

Subcellular Localizations

Cytoplasm. Cell projection, podosome. Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.

Diseases

Malignant Neoplasms
Neoplasms
Cell Invasion
Neoplasm Metastasis
Alzheimer's Disease
Melanoma
Neoplasm Invasiveness
Neurotoxicity Syndromes
Mammary Neoplasms
Invasive Malignant Neoplasm
Plaque, Amyloid
Tissue Adhesions
Senile Plaques

Extravasation
Metastatic Malignant Neoplasm To The Lung
Tumor Progression
Malignant Neoplasm Of Breast
Glioma
Malignant Tumor Of Colon
Bone Neoplasms

Interacting Proteins

ADAM15
Dnm1
SOS1

Pathways

Proteolysis
Cell Cycle
Cell Division
Macrophage Differentiation
Chemotaxis
Cell Motility
Cell Differentiation
Osteoclast Fusion

Angiogenesis
Cytokinesis

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SH3PXD2A

References

PMID: 12615925 by Abram C.L., et al. The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells.

PMID: 15710328 by Seals D.F., et al. The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells.