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- Table of Contents
SHBG Antibodies
AND SHBG ELISA kits, SHBG Proteins
Many biological assays use antibodies to detect SHBG, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SHBG in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SHBG antibodies...
Designing a Western blot for SHBG? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SHBG Western Blot GuideSHBG Infographic by Boster Bio
All SHBG Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK1236
96 wells/kit, with removable strips.
Cat # EK1236
96 wells/kit, with removable strips.
Human, Mouse, Rat
ELISA, IF, WB
$481
Cat # A00682
0.1 mg
Cat # A00682
0.1 mg
Human
$628
Cat # LS006462
20 µg, 100 µg
Cat # LS006462
20 µg, 100 µg
SHBG Overview
Facts about Sex hormone-binding globulin.
Sex hormone-binding globulin (SHBG)
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid.
Particular for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Gene Information
| Human | |
|---|---|
| Gene Name: | SHBG |
| Uniprot: | P04278 |
| Entrez: | 6462 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ABP; ABPTestosterone-estrogen-binding globulin; androgen binding protein; MGC126834; MGC138391; SBP; sex hormone-binding globulin; Sex steroid-binding protein; SHBG; TEBG; Testis-specific androgen-binding protein; testosterone-binding beta-globulin; Testosterone-estradiol-binding globulin
Molecular Weight
Mass (kDA):
43.779 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (7614064..7633383) |
Tissue Specificity
Isoform 1 and isoform 2 are present in liver and testis.
Subcellular Localizations
Secreted. In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.
Diseases
- Malignant Neoplasms
- Obesity
- Polycystic Ovary Syndrome
- Insulin Resistance
- Malignant Neoplasm Of Breast
- Diabetes Mellitus
- Mammary Neoplasms
- Cardiovascular Diseases
- Hypogonadism
- Insulin Sensitivity
- Hyperinsulinism
- Diabetes Mellitus, Non-insulin-dependent
Pathways
- Secretion
- Aging
- Menopause
- Pathogenesis
- Ovulation
- Transport
- Excretion
- Spermatogenesis
- Insulin Secretion
- Menarche
- Bone Resorption
- Coagulation
- Hormone Secretion
PTMs
- Glycosylation
- Phosphorylation
- Cleavage
- Oxidation
- Reduction
- Carboxylation
Research Areas
- Cancer
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SHBG
bosterbio.com/bosterbio-gene-info-cards/SHBG
References
PMID: 2587256 by Gershagen S., et al. Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis.
PMID: 2608061 by Hammond G.L., et al. The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs.