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- Table of Contents
SHC1 Antibodies
AND SHC1 ELISA kits, SHC1 Proteins
Many biological assays use antibodies to detect SHC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SHC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SHC1 antibodies...
Designing a Western blot for SHC1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SHC1 Western Blot GuideSHC1 Infographic by Boster Bio
All SHC1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, IHC-F, ICC, WB
$370
Cat # PA1897
100 μg/vial
Cat # PA1897
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00796-1
100 μl
Cat # M00796-1
100 μl
Human, Mouse, Rat
ELISA
$540
Cat # EKC1954
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1954
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1953
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1953
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1519
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1519
1 kit, containing one 96-well plate and all necessary reagents
SHC1 Overview
Facts about SHC-transforming protein 1.
SHC-transforming protein 1 (SHC1)
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF.
Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems.
Gene Information
| Human | |
|---|---|
| Gene Name: | SHC1 |
| Uniprot: | P29353 |
| Entrez: | 6464 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FLJ26504; p66; p66SHC; SH2 domain protein C1; SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1; SHC; SHC1; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1
Molecular Weight
Mass (kDA):
62.822 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q21.3 |
| Sequence: | 1; NC_000001.11 (154962298..154974492, complement) |
Tissue Specificity
Widely expressed. Expressed in neural stem cells but absent in mature neurons.
Subcellular Localizations
Cytoplasm.; [Isoform p46Shc]: Mitochondrion matrix. Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.; [Isoform p66Shc]: Mitochondrion. In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Tissue Adhesions
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Diabetes Mellitus
- Inflammation
- Leukemia
- Neoplasm Metastasis
- Neuroblastoma
- Atherosclerosis
Interacting Proteins
- APP
- AR
- CRK
- EGFR
- ERBB2
- ERBB3
- ERBB4
- GAB1
- GRB2
- IGF1R
Pathways
- Cell Proliferation
- Aging
- Cell Growth
- Cell Death
- Cell Cycle
- Pathogenesis
- Localization
- Cell Migration
- Senescence
- Endocytosis
- Angiogenesis
- Cell Differentiation
- Regeneration
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Methylation
- Reduction
- Oxidation
- Acetylation
- Ubiquitination
- Demethylation
Research Areas
- Cell Cycle and Replication
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SHC1
bosterbio.com/bosterbio-gene-info-cards/SHC1
References
PMID: 1623525 by Pelicci G., et al. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
PMID: 9049300 by Migliaccio E., et al. Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.