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- Table of Contents
Facts about SHC-transforming protein 1.
Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems.
Human | |
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Gene Name: | SHC1 |
Uniprot: | P29353 |
Entrez: | 6464 |
Belongs to: |
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No superfamily |
FLJ26504; p66; p66SHC; SH2 domain protein C1; SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1; SHC; SHC1; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1
Mass (kDA):
62.822 kDA
Human | |
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Location: | 1q21.3 |
Sequence: | 1; NC_000001.11 (154962298..154974492, complement) |
Widely expressed. Expressed in neural stem cells but absent in mature neurons.
Cytoplasm.; [Isoform p46Shc]: Mitochondrion matrix. Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.; [Isoform p66Shc]: Mitochondrion. In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation.
PMID: 1623525 by Pelicci G., et al. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
PMID: 9049300 by Migliaccio E., et al. Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.