Sin3a Antibodies

AND Sin3a ELISA kits, Sin3a Proteins

Many biological assays use antibodies to detect Sin3a, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sin3a in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sin3a antibodies...

We validate the specificity of these antibodies to Sin3a by testing them on tissues known to express Sin3a positively and negatively. Browse below to find the Sin3a antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Sin3a Infographic by Boster Bio

All Sin3a Products

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Product

Figures

Specificity

Applications

Price

Anti-mSin3A Rabbit Monoclonal Antibody

1 Citations 6 Q&As

Western blot analysis of mSin3A expression in (1) K562 cell lysate; (2) RAW 264

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M01203
100 μl

Anti-SIN3A Antibody

Western blot analysis of extracts of 293T cells, using Sin3A antibody at 1:1000 dilution

Human, Rat

$405
Cat # A01203
100ul

Anti-mSin3A Antibody

ICC staining mSin3A in Hela cells (green)

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$405
Cat # A01203-1
100ul

Anti-mSin3A/SIN3A Antibody Picoband®

1 Citations

Western blot analysis of mSin3A/SIN3A using anti-mSin3A/SIN3A antibody (A01203-2)

IHC analysis of mSin3A/SIN3A using anti-mSin3A/SIN3A antibody (A01203-2)

Human, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A01203-2
100 μg/vial

Sin3a Overview

Facts about Paired amphipathic helix protein Sin3a.

Paired amphipathic helix protein Sin3a (Sin3a)

Acts as a transcriptional repressor. Corepressor for REST.

Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA.

Gene Information

Mouse
Gene Name:	Sin3a
Uniprot:	Q60520
Entrez:	20466

Family

Belongs to:

No superfamily

Alternative Names

DKFZp434K2235; FLJ90319; Histone deacetylase complex subunit Sin3a; KIAA0700; paired amphipathic helix protein Sin3a; SIN3 homolog A, transcription regulator (yeast); SIN3 homolog A, transcriptional regulator (yeast); SIN3A; Transcriptional corepressor Sin3a; transcriptional co-repressor Sin3A; transcriptional regulator, SIN3A

Molecular Weight

Mass (kDA):
145.088 kDA

Genomic Context


Mouse

Location:	9 B\|9 30.89 cM
Sequence:	9;

Tissue Specificity

Widely expressed. Highest levels in testis, lung and thymus.

Diseases

Neoplasms
Malignant Neoplasms
Cell Transformation, Neoplastic
Leukemia
Sudden Infant Death Syndrome
Rett Syndrome
Malignant Neoplasm Of Breast
Metabolic Bone Disorder
Autistic Disorder
Traditional Serrated Adenoma
Mammary Neoplasms
Hyperplasia

Myeloid Leukemia
Nervousness
Immunologic Deficiency Syndromes
Sterility
Acute Leukemia
Chromosomal Translocation

Pathways

Methylation
Chromatin Remodeling
Cell Cycle
Dna Methylation
Localization
Gene Silencing
Histone Acetylation
Cell Growth
Histone Deacetylation
Cell Proliferation
Regulation Of Gene Expression
Cell Differentiation
Demethylation

Chromatin Modification
Atp-dependent Chromatin Remodeling
Translation
Embryo Development
Chromatin Organization
Dna Repair
Stem Cell Differentiation

PTMs

Methylation
Acetylation
Deacetylation
Phosphorylation
Demethylation

Sumoylation
Reduction
Hydroxylation
Cleavage
Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Sin3a

References

PMID: 7601471 by Halleck M.S., et al. A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3.

PMID: 8649810 by Rao G., et al. Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1.