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- Table of Contents
SKP2 Antibodies
AND SKP2 ELISA kits, SKP2 Proteins
Many biological assays use antibodies to detect SKP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SKP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SKP2 antibodies...
Designing a Western blot for SKP2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SKP2 Western Blot GuideSKP2 Infographic by Boster Bio
All SKP2 Products
Product
Figures
Specificity
Applications
Price
Anti-SKP2 Antibody Picoband®
3 Citations
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # PA1102
100 μg/vial
Cat # PA1102
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00544
100 μl
Cat # M00544
100 μl
Human
ELISA
$480
Cat # EKC1525
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1525
1 kit, containing one 96-well plate and all necessary reagents
SKP2 Overview
Facts about S-phase kinase-associated protein 2.
S-phase kinase-associated protein 2 (SKP2)
Substrate recognition element of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Degradation of CDKN1B/p27kip also needs CKS1.
Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and likely MYC, TOB1 and TAL1. Degradation of TAL1 also needs STUB1.
Gene Information
| Human | |
|---|---|
| Gene Name: | SKP2 |
| Uniprot: | Q13309 |
| Entrez: | 6502 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CDK2/cyclin A-associated protein p45; cyclin A/CDK2-associated protein p45; Cyclin-A/CDK2-associated protein p45; FBL1; F-box protein Skp2; F-box/LRR-repeat protein 1; FBXL1; FBXL1MGC1366; FLB1; p45skp2; Skp2; S-phase kinase-associated protein 2 (p45); S-phase kinase-associated protein 2
Molecular Weight
Mass (kDA):
47.761 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5p13.2 |
| Sequence: | 5; NC_000005.10 (36152043..36184319) |
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Retinoblastoma
- Mammary Neoplasms
- Malignant Squamous Cell Neoplasm
- Hyperplasia
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- Cdh1
- CDKN1A
- CDKN1B
- CKS1B
- CUL1
- DUSP1
- EP300
- FZR1
- KMT2A
- MYC
Pathways
- Cell Cycle
- Cell Proliferation
- Proteolysis
- S Phase
- Cell Growth
- Cell Cycle Arrest
- Pathogenesis
- G1 Phase
- Rna Interference
- Localization
- Mitosis
- Dna Replication
- Senescence
PTMs
- Phosphorylation
- Ubiquitination
- Dephosphorylation
- Cleavage
- Acetylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SKP2
bosterbio.com/bosterbio-gene-info-cards/SKP2
References
PMID: 7553852 by Zhang H., et al. p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase.
PMID: 12435635 by Tedesco D., et al. The pRb-related protein p130 is regulated by phosphorylation- dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2).
9 Publications of Boster SKP2 Antibodies & ELISA Kits
- PubMed ID: PMID:21270971, Small interfering RNA targeting of S phase kinase-interacting protein 2 inhibits...
- PubMed ID: 10.3892/mmr.2017.6793, MicroRNA-508-5p suppresses metastasis in human gastric cancer by targeting S-pha...
- PubMed ID: 20508867, Su Y, Wang F, Yan Q, Teng Y, Cui H. Mol Vis. 2010 May 25;16:907-15. Inhibition O...
- PubMed ID: 24788380, Xu F, Zhu X, Han T, You X, Liu F, Ye L, Zhang X, Wang X, Yao Y. Int J Oncol. 201...
- PubMed ID: 23352642, Xu F, You X, Liu F, Shen X, Yao Y, Ye L, Zhang X. Cancer Lett. 2013 Jun 1;333(1)...
- PubMed ID: 21270971, Su Y, Wang F, Qi H, Zhao Sg, Li X, Cui H. Mol Vis. 2011 Jan 22;17:247-56. Small ...
- PubMed ID: 23727062, Qiu J, Zhang C, Lv Y, Zhang Y, Zhu C, Wang X, Yao W. Neurochem Int. 2013 Aug;63(...
- PubMed ID: 25333250, Chen Xm, Xie Xb, Zhao Q, Wang F, Bai Y, Yin Jq, Jiang H, Xie Xl, Jia Q, Huang G....
- PubMed ID: 24265759, Chen Xm, Bai Y, Zhong Yj, Xie Xl, Long Hw, Yang Yy, Wu Sg, Jia Q, Wang Xh. Plos ...
*More publications can be found for each product on its corresponding product page