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- Table of Contents
SLC1A3 Antibodies
AND SLC1A3 ELISA kits, SLC1A3 Proteins
Many biological assays use antibodies to detect SLC1A3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC1A3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC1A3 antibodies...
Designing a Western blot for SLC1A3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SLC1A3 Western Blot GuideSLC1A3 Infographic by Boster Bio
All SLC1A3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A02133
100 μg/vial
Cat # A02133
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M02133-2
20μL, 40μL, 100μL, 200μL
Cat # M02133-2
20μL, 40μL, 100μL, 200μL
SLC1A3 Overview
Facts about Excitatory amino acid transporter 1.
Excitatory amino acid transporter 1 (SLC1A3)
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and a single proton, in parallel with the counter-transport of a single K(+) ion (PubMed:20477940).
Mediates Cl(-) flux that's not coupled to amino acid transport; this avoids the accumulation of negative charges because of aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is vital for terminating the postsynaptic action of glutamate (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | SLC1A3 |
| Uniprot: | P43003 |
| Entrez: | 6507 |
Family
| Belongs to: |
|---|
| dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family |
Alternative Names
EA6; EA6FLJ25094; EAAT1; EAAT1GLAST-1; excitatory amino acid transporter 1; GLAST; GLAST1; GLAST-1; GLASTGLAST1; SLC1A3; Sodium-dependent glutamate/aspartate transporter 1; solute carrier family 1 (glial high affinity glutamate transporter), member 3; Solute carrier family 1 member 3
Molecular Weight
Mass (kDA):
59.572 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5p13.2 |
| Sequence: | 5; NC_000005.10 (36606355..36688334) |
Tissue Specificity
Detected in brain (PubMed:8218410, PubMed:7521911, PubMed:8123008). Detected at very much lower levels in heart, lung, placenta and skeletal muscle (PubMed:7521911, PubMed:8123008). Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia (PubMed:7521911).
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Nervousness
- Ischemia
- Nerve Degeneration
- Sclerosis
- Gliosis
- Schizophrenia
- Epilepsy
- Brain Injuries
- Neurodegenerative Disorders
- Neurotoxicity Syndromes
- Malnutrition
- Hypoxia
Pathways
- Transport
- Localization
- Pathogenesis
- Cell Death
- Neurogenesis
- Neuroprotection
- Synaptic Transmission
- Glutamate Homeostasis
- Aging
- Cell Cycle
- Aspartate Transport
- Amino Acid Transport
- Cell Differentiation
PTMs
- Biotinylation
- Phosphorylation
- Carboxylation
- Glycosylation
- Oxidation
Research Areas
- Cellular Markers
- Cognition and Behavior
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC1A3
bosterbio.com/bosterbio-gene-info-cards/SLC1A3
References
PMID: 8218410 by Shashidharan P., et al. Cloning and characterization of a glutamate transporter cDNA from human cerebellum.
PMID: 7521911 by Arriza J.L., et al. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex.
3 Publications of Boster SLC1A3 Antibodies & ELISA Kits
- PubMed ID: 10.1038/s41467-021-25344-6, Improved modeling of human AD with an automated culturing platform for iPSC neur...
- PubMed ID: 28757163, Ho, S.M., Hartley, B.J., Flaherty, E., Rajarajan, P., Abdelaal, R., Obiorah, I.,...
- PubMed ID: 25371754, Ding Y, Zhang K, Liu S, Zhang Q, Ma C, Bruce Ic, Zhang X. Exp Ther Med. 2014 Dec...
*More publications can be found for each product on its corresponding product page