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Facts about Solute carrier family 22 member 6.
Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate.
Human | |
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Gene Name: | SLC22A6 |
Uniprot: | Q4U2R8 |
Entrez: | 9356 |
Belongs to: |
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major facilitator (TC 2.A.1) superfamily |
hOAT1; hPAHT; hROAT1; MGC45260; OAT1; OAT1FLJ55736; Organic anion transporter 1; PAH transporter; PAHT; PAHTHOAT1; para-aminohippurate transporter; Renal organic anion transporter 1; ROAT1; SLC22A6; solute carrier family 22 (organic anion transporter), member 6; solute carrier family 22 member 6
Mass (kDA):
61.816 kDA
Human | |
---|---|
Location: | 11q12.3 |
Sequence: | 11; NC_000011.10 (62976597..62984967, complement) |
Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule.
Cell membrane; Multi-pass membrane protein.
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The SLC22A6 gene encodes an enzyme with the molecular formula CYP3A4. The SLC22A6 gene is located on chromosome 11q12.3. The SLC22A6 protein plays a significant role in the transport of organic anion within the kidneys. The protein mediates the small organic anion hydrophilics being taken up. Boster Bio's antisLC22A6 marker identifies the C-terminal region of human SLC22A6.
There are numerous reasons to optimize experiments with Boster Bio. Apart from offering a variety of secondary antibodies and isotype controls, Boster Bio also offers detection systems that are optimized for IHC. Boster Bio answers many customer questions, including negative control conditions and the use an antibody that is a negative control. This article will discuss the benefits of optimizing research using Boster Bio.
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Before you try to solve common issues, make sure you have read the User Manual. Referring to the User Manual may make it easier to solve common problems. The SLC22A6 Marker is an electronic design, so you may have a glitch or two in the process. It's recommended to confirm if the marker is compatible with other paintball markers. Some models can be used with both electronic and mechanical cartridges.
PMID: 9762842 by Reid G., et al. Cloning of a human renal p-aminohippurate transporter, hROAT1.
PMID: 9887087 by Hosoyamada M., et al. Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney.
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