SLC26A8 Antibodies

AND SLC26A8 ELISA kits, SLC26A8 Proteins

Many biological assays use antibodies to detect SLC26A8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC26A8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC26A8 antibodies...

We validate the specificity of these antibodies to SLC26A8 by testing them on tissues known to express SLC26A8 positively and negatively. Browse below to find the SLC26A8 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC26A8 Infographic by Boster Bio

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SLC26A8 (NM_052961) Human Over-expression Lysate

Human

$960
Cat # LS116369
20 µg, 100 µg

SLC26A8 Overview

Facts about Testis anion transporter 1.

SLC26A8 3D structure. Source: alphafold

Testis anion transporter 1 (SLC26A8)

Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange purposes in male germ line through meiosis and hence may play a role in spermatogenesis.

May be involved with a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical part of the sperm annulus that is vital for correct sperm tail differentiation and motility and hence male fertility.

Gene Information

Human
Gene Name:	SLC26A8
Uniprot:	Q96RN1
Entrez:	116369

Family

Belongs to:

SLC26A/SulP transporter (TC 2.A.53) family

Alternative Names

solute carrier family 26, member 8

Molecular Weight

Mass (kDA):
109.006 kDA

Genomic Context


Human

Location:	6p21.31
Sequence:	6; NC_000006.12 (35943514..36024641, complement)

Tissue Specificity

Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa.

Subcellular Localizations

Membrane; Multi-pass membrane protein. Located at the annulus ring structure within the sperm cell.

Diseases

Male Infertility
Pendred's Syndrome
Dysplasia
Diastrophic Dysplasia
Diarrhea
Cystic Fibrosis
Congenital Secretory Diarrhea, Chloride Type
Sterility
Fibrosis
Complete Hearing Loss

Mucinous Adenocarcinoma
Hereditary Diseases
Hyperplastic Polyp
Tissue Adhesions
Infertility

Interacting Proteins

CFTR
RACGAP1

Pathways

Transport
Sperm Motility
Fertilization
Sulfate Transport
Localization
Protein Phosphorylation
Cell Motility
Amino Acid Transport

Sperm Capacitation
Anion Transport
Oxalate Transport

PTMs

Sulphation

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC26A8

References

PMID: 11278976 by Toure A., et al. Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling.

PMID: 11834742 by Lohi H., et al. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.