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- Table of Contents
3 Citations 17 Q&As
11 Citations 8 Q&As
Facts about Solute carrier family 2, facilitated glucose transporter member 4.
| Human | |
|---|---|
| Gene Name: | SLC2A4 |
| Uniprot: | P14672 |
| Entrez: | 6517 |

| Belongs to: |
|---|
| major facilitator superfamily |

Glut4; GLUT-4; GLUT4Glucose transporter type 4, insulin-responsive; insulin-responsive glucose transporter type 4; SLC2A4; solute carrier family 2 (facilitated glucose transporter), member 4; solute carrier family 2, facilitated glucose transporter member 4
Mass (kDA):
54.787 kDA

| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (7281718..7288257) |
Skeletal and cardiac muscles; brown and white fat.
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (PubMed:8300557). The dileucine internalization motif is critical for intracellular sequestration (PubMed:8300557). Insulin stimulation induces translocation to the cell membrane (By similarity).





PMID: 2656669 by Fukumoto H., et al. Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin- responsive tissues.
PMID: 1397719 by Buse J.B., et al. Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation.
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