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- Table of Contents
Zinc transporter ZIP8 Antibodies
AND SLC39A8 ELISA kits, Zinc transporter ZIP8 Proteins
Many biological assays use antibodies to detect Zinc transporter ZIP8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc transporter ZIP8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc transporter ZIP8 antibodies...
Designing a Western blot for Zinc transporter ZIP8? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SLC39A8 Western Blot GuideDesigning an IHC experiment for Zinc transporter ZIP8? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SLC39A8 IHC GuideSLC39A8 Infographic by Boster Bio
All SLC39A8 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A04007-1
100 μg/vial
Cat # A04007-1
100 μg/vial
SLC39A8 Overview
Facts about Zinc transporter ZIP8.
Zinc transporter ZIP8 (SLC39A8)
Acts as a manganese and zinc influx transporter (PubMed:12504855, PubMed:26637978). Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake to the brain (PubMed:26637978).
.
Gene Information
| Human | |
|---|---|
| Gene Name: | SLC39A8 |
| Uniprot: | Q9C0K1 |
| Entrez: | 64116 |
Family
| Belongs to: |
|---|
| ZIP transporter (TC 2.A.5) family |
Alternative Names
BCG induced integral membrane protein BIGM103; BIGM103BCG-induced integral membrane protein in monocyte clone 103 protein; LIV-1 subfamily of ZIP zinc transporter 6; LZT-Hs6; solute carrier family 39 (metal ion transporter), member 8; solute carrier family 39 (zinc transporter), member 8; Solute carrier family 39 member 8; zinc transporter ZIP8; ZIP8; ZIP-8; Zrt- and Irt-like protein 8
Molecular Weight
Mass (kDA):
49.631 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q24 |
| Sequence: | 4; NC_000004.12 (102251041..102345482, complement) |
Tissue Specificity
Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas.
Subcellular Localizations
Membrane; Multi-pass membrane protein. Associated with the lysosomal/endosomal compartment following transfection.
Diseases
- Inflammation
- Testicular Necrosis
- Fibrosis
- Zinc Deficiency Disorder
- Anemia
- Kidney Failure
- Cystic Fibrosis
- Disease Of Adrenal Medulla
- Overlying Behavior
- Malaria, Falciparum
- Lung Diseases
- Coronary Artery Disease
Pathways
- Transport
- Localization
- Cell Death
- Secretion
- Receptor-mediated Endocytosis
- Cell Adhesion
- Cell Activation
- Cell Proliferation
- Gastrulation
- Dna Hypermethylation
- Insulin Secretion
- T Cell Activation
- Tube Formation
PTMs
- Glycosylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC39A8
bosterbio.com/bosterbio-gene-info-cards/SLC39A8
References
PMID: 12504855 by Begum N.A., et al. Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures.
PMID: 26637978 by Boycott K.M., et al. Autosomal-recessive intellectual disability with cerebellar atrophy syndrome caused by mutation of the manganese and zinc transporter gene SLC39A8.