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- Table of Contents
SLC4A1 Antibodies
AND SLC4A1 ELISA kits, SLC4A1 Proteins
Many biological assays use antibodies to detect SLC4A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC4A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC4A1 antibodies...
Designing a Western blot for SLC4A1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SLC4A1 Western Blot GuideSLC4A1 Infographic by Boster Bio
All SLC4A1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, WB
$370
Cat # PB9437
100 μg/vial
Cat # PB9437
100 μg/vial
Human
Flow Cytometry, IHC, WB
$370
Cat # M01146-1
100 μg/vial
Cat # M01146-1
100 μg/vial
Human
IF, IHC, ICC, WB
$370
Cat # M01146
100 μl/vial
Cat # M01146
100 μl/vial
Human
$960
Cat # LS022950
20 µg, 100 µg
Cat # LS022950
20 µg, 100 µg
SLC4A1 Overview
Facts about Band 3 anion transport protein.
Band 3 anion transport protein (SLC4A1)
Functions both as a transporter that mediates electroneutral anion exchange throughout the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape through the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin.
Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.
Gene Information
| Human | |
|---|---|
| Gene Name: | SLC4A1 |
| Uniprot: | P02730 |
| Entrez: | 6521 |
Family
| Belongs to: |
|---|
| anion exchanger (TC 2.A.31) family |
Alternative Names
AE 1; AE1MGC126619; Anion exchange protein 1; Anion exchanger 1; band 3 anion transport protein; BND3; CD233 antigen; CD233; DI; EMPB3; EPB3MGC126623; erythrocyte membrane protein band 3; erythroid anion exchange protein; FR; Froese blood group; MGC116750; MGC116753; RTA1A; Solute carrier family 4 member 1; solute carrier family 4, anion exchanger, member 1 (erythrocyte membraneprotein band 3, Diego blood group); solute carrier family 4, anion exchanger, number 1; SW; Swann blood group; Waldner blood group; WD; WD1; WR; Wright blood group
Molecular Weight
Mass (kDA):
101.792 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.31 |
| Sequence: | 17; NC_000017.11 (44248390..44268161, complement) |
Tissue Specificity
Detected in erythrocytes (at protein level) (PubMed:7506871, PubMed:26542571). Isoform 2 is expressed in kidney (at protein level) (PubMed:7506871).
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Detected in the erythrocyte cell membrane and on the basolateral membrane of alpha-intercalated cells in the collecting duct in the kidney.
Diseases
- Renal Tubular Acidosis
- Acidosis
- Renal Tubular Acidosis, Type I
- Anemia
- Elliptocytosis, Hereditary
- Hereditary Spherocytosis
- Anemia, Hemolytic
- Stomatocytic Anemia
- Metabolic Acidosis
- Anemia, Hemolytic, Congenital
- Hereditary Stomatocytosis
- Malaria
Interacting Proteins
- ATP1B1
- GYPA
- STOM
Pathways
- Transport
- Anion Transport
- Secretion
- Localization
- Bicarbonate Transport
- Excretion
- Pathogenesis
- Cation Transport
- Acid Secretion
- Iodide Transport
- Sulfate Transport
- Ion Transport
- Glycosylation
PTMs
- Phosphorylation
- Glycosylation
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC4A1
bosterbio.com/bosterbio-gene-info-cards/SLC4A1
References
PMID: 3223947 by Tanner M.J.A., et al. The complete amino acid sequence of the human erythrocyte membrane anion-transport protein deduced from the cDNA sequence.
PMID: 2594752 by Lux S.E., et al. Cloning and characterization of band 3, the human erythrocyte anion- exchange protein (AE1).