Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to connect them to the actin cytoskeleton and to regulate their surface expression. Was known to play a role in the regulation of the activity and subcellular location of SLC9A3.

Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May improve Wnt signaling.