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- Table of Contents
SLU7 Antibodies
AND SLU7 ELISA kits, SLU7 Proteins
Many biological assays use antibodies to detect SLU7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLU7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLU7 antibodies...
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SLU7 Infographic by Boster Bio
All SLU7 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$399
Cat # A07557
100μl
Cat # A07557
100μl
Human, Mouse, Rat
IHC, WB
$523
Cat # M07557
100 µl
Cat # M07557
100 µl
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A07557-2
100 μg/vial
Cat # A07557-2
100 μg/vial
SLU7 Overview
Facts about Pre-mRNA-splicing factor SLU7.
Pre-mRNA-splicing factor SLU7 (SLU7)
Participates in the second catalytic step of pre-mRNA splicing, once the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for proper AG identification when more than one possible AG exists in 3'-splicing site area.
May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
Gene Information
| Human | |
|---|---|
| Gene Name: | SLU7 |
| Uniprot: | O95391 |
| Entrez: | 10569 |
Family
| Belongs to: |
|---|
| SLU7 family |
Alternative Names
hSlu7; MGC9280; pre-mRNA-splicing factor SLU7,9G8; SLU7 splicing factor homolog (S. cerevisiae); splicing factor; step II splicing factor SLU7; zinc knuckle motif containing
Molecular Weight
Mass (kDA):
68.387 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q33.3 |
| Sequence: | 5; NC_000005.10 (160401641..160419081, complement) |
Subcellular Localizations
Nucleus. Nucleus speckle. Cytoplasm. Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.
Diseases
- Cell Transformation, Neoplastic
- Primary Neoplasm
- Liver Carcinoma
- Chronic Inflammation
- Inflammatory Bowel Diseases
- Hepatocarcinogenesis
- Autoimmune Diseases
- Intestinal Diseases
- Physiological Stress
- Carcinoma
- Ulcerative Colitis
- Ulcer
Interacting Proteins
- CEP70
- GOLGA2
- KRT40
- LZTS2
- NSD3
- PPIL3
- PRPF3
- PRPF8
- SF3B2
- THAP1
Pathways
- Rna Splicing
- Transport
- Cell Division
- Mrna Splicing
- Cellular Localization
- Hypersensitivity
- Cell Growth
- Pathogenesis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLU7
bosterbio.com/bosterbio-gene-info-cards/SLU7
References
PMID: 10197984 by Chua K., et al. Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing.
PMID: 10647016 by Chua K., et al. The RNA splicing factor hSlu7 is required for correct 3' splice-site choice.