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- Table of Contents
SMARCA1 Antibodies
AND SMARCA1 ELISA kits, SMARCA1 Proteins
Many biological assays use antibodies to detect SMARCA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMARCA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMARCA1 antibodies...
Designing an IHC experiment for SMARCA1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SMARCA1 IHC GuideSMARCA1 Infographic by Boster Bio
All SMARCA1 Products
Product
Figures
Specificity
Applications
Price
SMARCA1 Overview
Facts about Probable global transcription activator SNF2L1.
Probable global transcription activator SNF2L1 (SMARCA1)
Energy-transducing component of NURF (nucleosome- remodeling factor) and CERF (CECR2-containing-remodeling variable ) complexes. Both complexes ease the perturbation of chromatin structure in an ATP-dependent manner.
Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression.
Gene Information
| Human | |
|---|---|
| Gene Name: | SMARCA1 |
| Uniprot: | P28370 |
| Entrez: | 6594 |
Family
| Belongs to: |
|---|
| SNF2/RAD54 helicase family |
Alternative Names
ATP-dependent helicase SMARCA1; DKFZp686D1623; EC 3.6.1; EC 3.6.4.-; FLJ41547; global transcription activator homologous sequence; Nucleosome-remodeling factor subunit SNF2L; NURF140; probable global transcription activator SNF2L1; SNF2L; SNF2L1ISWI; SNF2LB; SNF2-like 1; SNF2LT; subfamily a, member 1; sucrose nonfermenting 2-like protein 1; SWI; SWI/SNF related, matrix associated, actin dependent regulator of chromatin; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily A member 1; SWI2
Molecular Weight
Mass (kDA):
122.605 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq25-q26.1 |
| Sequence: | X; NC_000023.11 (129446501..129523520, complement) |
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Retinoblastoma
- Carcinoma
- Hyperplasia
- Neoplasm Metastasis
- Papilloma
- Williams Syndrome
- Testicular Hypogonadism
- Melanoma
Interacting Proteins
- BPTF
Pathways
- Chromatin Remodeling
- Dna Repair
- Atp-dependent Chromatin Remodeling
- Cell Cycle
- Cell Growth
- Methylation
- Nucleosome Positioning
- Mitosis
- Brain Development
- Cell Division
- Histone Acetylation
- Cell Proliferation
- Dna Methylation
PTMs
- Phosphorylation
- Methylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMARCA1
bosterbio.com/bosterbio-gene-info-cards/SMARCA1
References
PMID: 1408766 by Okabe I., et al. Cloning of human and bovine homologs of SNF2/SWI2: a global activator of transcription in yeast S. cerevisiae.
PMID: 15310751 by Barak O., et al. A tissue-specific, naturally occurring human SNF2L variant inactivates chromatin remodeling.