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- Table of Contents
SMARCA2 Antibodies
AND SMARCA2 ELISA kits, SMARCA2 Proteins
Many biological assays use antibodies to detect SMARCA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMARCA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMARCA2 antibodies...
Designing a Western blot for SMARCA2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SMARCA2 Western Blot GuideDesigning an IHC experiment for SMARCA2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SMARCA2 IHC GuideSMARCA2 Infographic by Boster Bio
All SMARCA2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01888-3
100 μg/vial
Cat # A01888-3
100 μg/vial
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # M01888
100 μg/vial
Cat # M01888
100 μg/vial
Human
IF, ICC, WB
$370
Cat # M01888-1
100 μg/vial
Cat # M01888-1
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01888-2
100 μg/vial
Cat # A01888-2
100 μg/vial
SMARCA2 Overview
Facts about Probable global transcription activator SNF2L2.
Probable global transcription activator SNF2L2 (SMARCA2)
Component of SWI/SNF chromatin remodeling complexes that carry out crucial enzymatic actions, changing chromatin structure by altering DNA-histone contacts within a nucleosome within an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204).
Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) as well as the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become dedicated to their adult condition.
Gene Information
| Human | |
|---|---|
| Gene Name: | SMARCA2 |
| Uniprot: | P51531 |
| Entrez: | 6595 |
Family
| Belongs to: |
|---|
| SNF2/RAD54 helicase family |
Alternative Names
ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated factor 190B; BRMFLJ36757; EC 3.6.1; EC 3.6.4.-; global transcription activator homologous sequence; hBRMMGC74511; hSNF2a; probable global transcription activator SNF2L2; Protein brahma homolog; SNF2; SNF2/SWI2-like protein 2; SNF2A; SNF2-alpha; SNF2L2BAF190; SNF2LA; SNF2-like 2; Sth1p; subfamily a, member 2; sucrose nonfermenting 2-like protein 2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2; SWI/SNF-related matrix-associated actin-
Molecular Weight
Mass (kDA):
181.279 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p24.3 |
| Sequence: | 9; NC_000009.12 (2015347..2193624) |
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Retinoblastoma
- Carcinoma
- Cell Transformation, Neoplastic
- Growth Arrest
- Mammary Neoplasms
- Adenocarcinoma
- Leukemia
- Immunologic Deficiency Syndromes
- Hyperplasia
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- ARID1A
- ARID1B
- KHDRBS1
- MECP2
- SDCBP
Pathways
- Chromatin Remodeling
- Cell Cycle
- Dna Repair
- Methylation
- Atp-dependent Chromatin Remodeling
- Cell Growth
- Cell Proliferation
- Dna Methylation
- Senescence
- Cell Cycle Arrest
- Mitosis
- S Phase
- Pathogenesis
PTMs
- Methylation
- Phosphorylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMARCA2
bosterbio.com/bosterbio-gene-info-cards/SMARCA2
References
PMID: 8223438 by Muchardt C., et al. A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor.
PMID: 8208605 by Chiba H., et al. Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor.