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- Table of Contents
SMARCA5 Antibodies
AND SMARCA5 ELISA kits, SMARCA5 Proteins
Many biological assays use antibodies to detect SMARCA5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMARCA5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMARCA5 antibodies...
Designing an IHC experiment for SMARCA5? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SMARCA5 IHC GuideSMARCA5 Infographic by Boster Bio
All SMARCA5 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02687-1
100 μg/vial
Cat # A02687-1
100 μg/vial
SMARCA5 Overview
Facts about SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5.
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5)
Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require complete histone H4 tails.
Also needed for replication of pericentric heterochromatin in S-phase especially in combination with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of this SIN3/HDAC1 corepressor complex to the rDNA promoter.
Gene Information
| Human | |
|---|---|
| Gene Name: | SMARCA5 |
| Uniprot: | O60264 |
| Entrez: | 8467 |
Family
| Belongs to: |
|---|
| SNF2/RAD54 helicase family |
Alternative Names
EC 3.6.1; EC 3.6.4.-; hISWI; hSNF2HSWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; ISWI; SMARCA5; SNF2H; SNF2Hsucrose nonfermenting-like 5; subfamily a, member 5; Sucrose nonfermenting protein 2 homolog; SWI/SNF related, matrix associated, actin dependent regulator of chromatin; SWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily A member 5; WCRF135
Molecular Weight
Mass (kDA):
121.905 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q31.21 |
| Sequence: | 4; NC_000004.12 (143513501..143557486) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Williams Syndrome
- Carcinoma
- Carcinogenesis
- Malignant Paraganglionic Neoplasm
- Chromosomal Translocation
- Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)
- Cell Transformation, Neoplastic
- Sarcoma
- Immunologic Deficiency Syndromes
- Genomic Instability
- Prostatic Neoplasms
Interacting Proteins
- BAZ1A
- BAZ1B
- HIST1H4A
- RSF1
Pathways
- Chromatin Remodeling
- Atp-dependent Chromatin Remodeling
- Methylation
- Cell Cycle
- Dna Methylation
- S Phase
- Localization
- Dna Replication
- Chromatin Assembly
- Cell Proliferation
- Nucleosome Positioning
- Cell Death
- Mitosis
PTMs
- Methylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMARCA5
bosterbio.com/bosterbio-gene-info-cards/SMARCA5
References
PMID: 9730600 by Aihara T., et al. Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI.
PMID: 10880450 by Poot R.A., et al. HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins.