Protein SMG8 (SMG8)

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complicated, is required to mediate the recruitment of SMG1 into the ribosome:SURF complicated and to suppress SMG1 kinase activity until the ribosome:SURF complicated finds the exon junction complex (EJC).

Acts as a regulator of kinase activity. .