Transcription factor Sp7 Antibodies

AND SP7 ELISA kits, Transcription factor Sp7 Proteins

Many biological assays use antibodies to detect Transcription factor Sp7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor Sp7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor Sp7 antibodies...

We validate the specificity of these antibodies to Transcription factor Sp7 by testing them on tissues known to express SP7 positively and negatively. Browse below to find the SP7 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SP7 Infographic by Boster Bio

All SP7 Products

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Specificity

Applications

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Anti-Transcription factor Sp7 SP7 Antibody

Western blot analysis of lysates from HCT116 cells, primary antibody was diluted at 1:1000, 4°over night

Human, Mouse

ELISA, WB

$380
Cat # A02077
100ul

Anti-Sp7/Osterix Antibody Picoband®

8 Citations

Western blot analysis of Sp7/Osterix using anti-Sp7/Osterix antibody (A02077-1)

KCNMA1-AS1 is upregulated when hBMSCs undergo osteogenic differentiation

KCNMA1-AS1 promotes osteogenic differentiation of hBMSCs in vitro

Human, Mouse, Rat

ELISA, WB

$370
Cat # A02077-1
100 μg/vial

SP7 (NM_152860) Human Over-expression Lysate

Human

$628
Cat # LS121340
20 µg, 100 µg

Anti-Osterix/SP7 Antibody (Monoclonal, 33S10)

Human, Mouse, Rat

IF, IHC, WB

$370
Cat # M02077
100 μl/vial

SP7 Overview

Facts about Transcription factor Sp7.

SP7 3D structure. Source: alphafold

Transcription factor Sp7 (SP7)

Transcriptional activator essential for osteoblast differentiation (PubMed:23457570). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity).

Gene Information

Human
Gene Name:	SP7
Uniprot:	Q8TDD2
Entrez:	121340

Family

Belongs to:

Sp1 C2H2-type zinc-finger protein family

Alternative Names

MGC126598; Osterix; OSX; OSXosterix; Sp7 transcription factor; Sp7; transcription factor Sp7; Zinc finger protein osterix

Molecular Weight

Mass (kDA):
44.994 kDA

Genomic Context


Human

Location:	12q13.13
Sequence:	12; NC_000012.12 (53326575..53344793, complement)

Tissue Specificity

Restricted to bone-derived cell.

Subcellular Localizations

Nucleus.

Diseases

Fracture
Bone Diseases
Osteoporosis
Neoplasms
Multiple Myeloma
Osteogenesis Imperfecta
Hypertrophy
Osteosarcoma
Malignant Paraganglionic Neoplasm
Dental Plaque
Tissue Adhesions
Atherosclerosis
Pneumonia

Bone Neoplasms
Osteopenia
Craniosynostosis
Physiological Stress
Degenerative Polyarthritis
Calcinosis
Osteoid Osteoma

Pathways

Osteoblast Differentiation
Nitrogen Fixation
Cell Differentiation
Cell Proliferation
Ossification
Regeneration
Bone Development
Chondrocyte Differentiation
Transport
Chemotaxis
Localization
Secretion
Flocculation

Pathogenesis
Cell Growth
Regulation Of Osteoblast Differentiation
Bone Remodeling
Bone Resorption
Colony Morphology
Osteoblast Proliferation

PTMs

Phosphorylation
Nitration
Oxidation
Methylation
Sumoylation

Hydroxylation
Amidation
Acetylation
Ribosylation
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SP7

References

PMID: 11792318 by Nakashima K., et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation.

PMID: 14604442 by Milona M.-A., et al. Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells.

2 Publications of Boster Transcription factor Sp7 Antibodies & ELISA Kits

PubMed ID: 10.1111/j.1757-7861.2010.00100.x, Dynamic expression of Runx2, Osterix and AJ18 in the femoral head of steroid‐i...
PubMed ID: 32018039, Chen G,Wang Q,Li Z,Yang Q,Liu Y,Du Z,Zhang G,Song Y.Circular RNA CDR1as promotes...

*More publications can be found for each product on its corresponding product page