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- Table of Contents
Facts about Striated muscle preferentially expressed protein kinase.
Human | |
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Gene Name: | SPEG |
Uniprot: | Q15772 |
Entrez: | 10290 |
Belongs to: |
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protein kinase superfamily |
aortic preferentially expressed gene 1; Aortic preferentially expressed protein 1; APEG1; BPEG; EC 2.7.11; EC 2.7.11.1; KIAA1297APEG-1; MGC12676; nuclear protein, marker for differentiated aortic smooth muscle anddown-regulated with vascular injury; SPEG complex locus; SPEGalpha; SPEGbeta; striated muscle preferentially expressed protein kinase
Mass (kDA):
354.289 kDA
Human | |
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Location: | 2q35 |
Sequence: | 2; NC_000002.12 (219434215..219493629) |
Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis.
[Isoform 3]: Nucleus.
PMID: 8663449 by Hsieh C.-M., et al. APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury.
PMID: 16545539 by Tam J.L.Y., et al. The human desmin locus: gene organization and LCR-mediated transcriptional control.