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- Table of Contents
SREBF2 Antibodies
AND SREBF2 ELISA kits, SREBF2 Proteins
Many biological assays use antibodies to detect SREBF2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SREBF2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SREBF2 antibodies...
Designing a Western blot for SREBF2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SREBF2 Western Blot GuideDesigning an IHC experiment for SREBF2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SREBF2 IHC GuideSREBF2 Infographic by Boster Bio
All SREBF2 Products
Product
Figures
Specificity
Applications
Price
Anti-SREBP2/SREBF2 Antibody Picoband®
2 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01678-2
100 μg/vial
Cat # A01678-2
100 μg/vial
SREBF2 Overview
Facts about Sterol regulatory element-binding protein 2.
Sterol regulatory element-binding protein 2 (SREBF2)
Transcriptional activator necessary for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity).
Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') located in the flanking region of the LDRL and HMG-CoA synthase genes. .
Gene Information
| Human | |
|---|---|
| Gene Name: | SREBF2 |
| Uniprot: | Q12772 |
| Entrez: | 6721 |
Family
| Belongs to: |
|---|
| SREBP family |
Alternative Names
bHLhd2; bHLHd2sterol regulatory element-binding protein 2; Class D basic helix-loop-helix protein 2; SREBF2; SREBP2; SREBP2SREBP-2; sterol regulatory element binding transcription factor 2; Sterol regulatory element-binding transcription factor 2
Molecular Weight
Mass (kDA):
123.688 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.2 |
| Sequence: | 22; NC_000022.11 (41833105..41907308) |
Tissue Specificity
Ubiquitously expressed in adult and fetal tissues.
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.; [Processed sterol regulatory element-binding protein 2]: Nucleus.
Diseases
- Obesity
- Hypercholesterolemia
- Atherosclerosis
- Malignant Neoplasms
- Insulin Resistance
- Diabetes Mellitus
- Fatty Liver
- Liver Carcinoma
- Hyperlipidemia
- Dyslipidemias
- Inflammation
- Neoplasms
- Steatosis
Interacting Proteins
- CREBBP
- HNF4A
- MED15
- SP1
- TP53
Pathways
- Cholesterol Homeostasis
- Secretion
- Lipid Homeostasis
- Transport
- Proteolysis
- Cholesterol Efflux
- Pathogenesis
- Cell Growth
- Localization
- Cell Proliferation
- Intestinal Cholesterol Absorption
- Cholesterol Transport
- Cell Death
PTMs
- Cleavage
- Phosphorylation
- Oxidation
- Reduction
- Ubiquitination
- Sumoylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SREBF2
bosterbio.com/bosterbio-gene-info-cards/SREBF2
References
PMID: 7903453 by Hua X., et al. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.
PMID: 8402897 by Yokoyama C., et al. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.