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- Table of Contents
SRSF1 Antibodies
AND SRSF1 ELISA kits, SRSF1 Proteins
Many biological assays use antibodies to detect SRSF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SRSF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SRSF1 antibodies...
Designing a Western blot for SRSF1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SRSF1 Western Blot GuideDesigning an IHC experiment for SRSF1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SRSF1 IHC GuideSRSF1 Infographic by Boster Bio
All SRSF1 Products
Product
Figures
Specificity
Applications
Price
Anti-SF2 Monoclonal Antibody
1 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00497
100 μl
Cat # M00497
100 μl
SRSF1 Overview
Facts about Serine/arginine-rich splicing factor 1.
Serine/arginine-rich splicing factor 1 (SRSF1)
Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF.
Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=G or A ) or the decamers, AGGACAGAGC/AGGACGAAGC.
Gene Information
| Human | |
|---|---|
| Gene Name: | SRSF1 |
| Uniprot: | Q07955 |
| Entrez: | 6426 |
Family
| Belongs to: |
|---|
| splicing factor SR family |
Alternative Names
Alternative-splicing factor 1; ASFpre-mRNA-splicing factor SF2, P33 subunit; MGC5228; serine/arginine-rich splicing factor 1; SF2FLJ53078; SF2p33; SFRS1splicing factor 2; Splicing factor, arginine/serine-rich 1ASF-1; SR splicing factor 1; SRp30a
Molecular Weight
Mass (kDA):
27.745 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q22 |
| Sequence: | 17; NC_000017.11 (58000919..58007346, complement) |
Subcellular Localizations
Cytoplasm. Nucleus speckle. In nuclear speckles. Shuttles between the nucleus and the cytoplasm (PubMed:12215544, PubMed:20308322, PubMed:9420331, PubMed:24449914). Nuclear import is mediated via interaction with TNPO3 (PubMed:24449914).
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Tumor Angiogenesis
- Pathologic Neovascularization
- Malignant Neoplasm Of Lung
- Adenocarcinoma
- Non-small Cell Lung Carcinoma
- Adenocarcinoma Of Lung (disorder)
- Denys-drash Syndrome
- Leukemia
Interacting Proteins
- CIR1
- NFYA
- NXF1
- RRP1B
- SNRNP70
- SRPK1
- Srpk1
- Srpk2
- TRAF5
- U2AF1
Pathways
- Localization
- Hyperphosphorylation
- Angiogenesis
- Aging
- Mrna Splicing
- Translation
- Cell Differentiation
- Rna Splicing
- Cellular Localization
- Transport
- Protein Phosphorylation
- Cell Migration
- Cellular Senescence
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SRSF1
bosterbio.com/bosterbio-gene-info-cards/SRSF1
References
PMID: 1855257 by Ge H., et al. Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators.
PMID: 1830244 by Krainer A.R., et al. Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators.