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Cohesin subunit SA-1 Antibodies
AND STAG1 ELISA kits, Cohesin subunit SA-1 Proteins
Many biological assays use antibodies to detect Cohesin subunit SA-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cohesin subunit SA-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cohesin subunit SA-1 antibodies...
Designing a Western blot for Cohesin subunit SA-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the STAG1 Western Blot GuideSTAG1 Infographic by Boster Bio
All STAG1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A06471-1
100 µg/vial
Cat # A06471-1
100 µg/vial
STAG1 Overview
Facts about Cohesin subunit SA-1.
Cohesin subunit SA-1 (STAG1)
Part of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped.
At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | STAG1 |
| Uniprot: | Q8WVM7 |
| Entrez: | 10274 |
Family
| Belongs to: |
|---|
| SCC3 family |
Alternative Names
cohesin subunit SA-1; nuclear protein stromal antigen 1; SA1; stromal antigen 1
Molecular Weight
Mass (kDA):
144.427 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q22.3 |
| Sequence: | 3; NC_000003.12 (136336235..136752412, complement) |
Subcellular Localizations
Nucleus. Chromosome. Chromosome, centromere. Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
Diseases
- Malignant Neoplasms
- Neoplasms
- Kidney Neoplasm
- Carcinoma
- Renal Cell Carcinoma
- Malignant Neoplasm Of Prostate
- Adenocarcinoma
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Stomach Neoplasms
- Malignant Neoplasm Of Breast
- Von Hippel-lindau Syndrome
- Neoplasms, Experimental
Interacting Proteins
- PDS5A
- PDS5B
- SMC3
- STAG2
- TERF1
Pathways
- Sister Chromatid Cohesion
- Mitosis
- Diplotene
- Localization
- Dna Replication
- Translation
- Cell Cycle
- Proteolysis
- Dna Repair
- Metaphase
- Chromosome Segregation
- Anaphase
- Cell Maturation
PTMs
- Isopeptide bond
Research Areas
- Cell Cycle and Replication
- DNA Repair
- Mitotic Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STAG1
bosterbio.com/bosterbio-gene-info-cards/STAG1
References
PMID: 9305759 by Carramolino L., et al. SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs.
PMID: 11076961 by Sumara I., et al. Characterization of vertebrate cohesin complexes and their regulation in prophase.