Syntaxin-4 Antibodies

AND STX4 ELISA kits, Syntaxin-4 Proteins

Many biological assays use antibodies to detect Syntaxin-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Syntaxin-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Syntaxin-4 antibodies...

We validate the specificity of these antibodies to Syntaxin-4 by testing them on tissues known to express STX4 positively and negatively. Browse below to find the STX4 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Syntaxin-4? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the STX4 IHC Guide

STX4 Infographic by Boster Bio

All STX4 Products

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Specificity

Applications

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Anti-Syntaxin 4/STX4 Antibody Picoband®

Western blot analysis of Syntaxin 4/STX4 using anti-Syntaxin 4/STX4 antibody (A05345-1)

IHC analysis of Syntaxin 4/STX4 using anti-Syntaxin 4/STX4 antibody (A05345-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # A05345-1
100 μg/vial

Anti-Syntaxin 4 Rabbit Monoclonal Antibody

All lanes use the Antibody at 1:6K dilution for 1 hour at room temperature

Western blot analysis of Syntaxin 4 expression in A431 cell lysate

Human, Mouse, Rat

$370
Cat # M05345
100 μl/vial

Syntaxin 4 (STX4) (NM_004604) Human Over-expression Lysate

Human

$628
Cat # LS006810
20 µg, 100 µg

Human Syntaxin 4 Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ12846
Starting from 20ug

STX4 Overview

Facts about Syntaxin-4.

STX4 3D structure. Source: alphafold

Syntaxin-4 (STX4)

Plasma membrane t-SNARE which mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane.

Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.

Gene Information

Human
Gene Name:	STX4
Uniprot:	Q12846
Entrez:	6810

Family

Belongs to:

syntaxin family

Alternative Names

NY-REN-31; p35-2; Renal carcinoma antigen NY-REN-31; STX4; STX4Ap35-2; Syntaxin 4; syntaxin 4A (placental); syntaxin-4

Molecular Weight

Mass (kDA):
34.18 kDA

Genomic Context


Human

Location:	16p11.2
Sequence:	16; NC_000016.10 (31033095..31040168)

Tissue Specificity

Expressed in neutrophils and neutrophil- differentiated HL-60 cells. Expression in neutrophils increases with differentiation.

Subcellular Localizations

Cell membrane; Single-pass type IV membrane protein.

Diseases

Tissue Adhesions
Autoimmunity
Hypertensive Disease
Disease Of Adrenal Medulla
Essential Hypertension
Autoimmune Reaction
Salivary Gland Diseases
Sjogren's Syndrome

Xerostomia
Inflammation
Autoimmune Diseases

Interacting Proteins

BET1
CYBRD1
EMD
GIMAP5
GOSR2

NAPA
NAPB
PSMA3
SEC22A
SEC22B

SNAP47
STX12
STX16
STX1A
STX3

STX5
STX6
STX7
STX8
VAMP1

VAMP2
VAMP3
VAMP4
VAMP5
VTI1B

Pathways

Exocytosis
Membrane Fusion
Cell Migration
Localization
Vesicle Docking
Pathogenesis
Vesicle Fusion

Secretion

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STX4

References

PMID: 8206394 by Li H., et al. Isolation and sequence analysis of the human syntaxin-encoding gene.

PMID: 8760387 by Jagadish M.N., et al. Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2.