SUCLA2 Antibodies

AND SUCLA2 ELISA kits, SUCLA2 Proteins

Many biological assays use antibodies to detect SUCLA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SUCLA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SUCLA2 antibodies...

We validate the specificity of these antibodies to SUCLA2 by testing them on tissues known to express SUCLA2 positively and negatively. Browse below to find the SUCLA2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for SUCLA2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the SUCLA2 Western Blot Guide

SUCLA2 Infographic by Boster Bio

All SUCLA2 Products

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Specificity

Applications

Price

Anti-SUCLA2 Antibody Picoband®

Western blot analysis of SUCLA2 using anti-SUCLA2 antibody (A04807-1)

IF analysis of SUCLA2 using anti-SUCLA2 antibody (A04807-1)

Flow Cytometry analysis of THP-1 cells using anti-SUCLA2 antibody (A04807-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A04807-1
100 µg/vial

SUCLA2 (NM_003850) Human Over-expression Lysate

Human

$628
Cat # LS008803
20 µg, 100 µg

SUCLA2 Overview

Facts about Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial.

SUCLA2 3D structure. Source: alphafold

Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2)

ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA into the synthesis of ATP and so represents the only step of substrate-level phosphorylation in the TCA (PubMed:15877282). The beta subunit offers nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are present in the alpha subunit (By similarity).

Gene Information

Human
Gene Name:	SUCLA2
Uniprot:	Q9P2R7
Entrez:	8803

Family

Belongs to:

succinate/malate CoA ligase beta subunit family

Alternative Names

A-BETA; ATP-specific succinyl-CoA synthetase subunit beta; beta subunit; EC 6.2.1; EC 6.2.1.5; mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta; MTDPS5; Renal carcinoma antigen NY-REN-39; succinate-CoA ligase, ADP-forming, beta subunit; succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial

Molecular Weight

Mass (kDA):
50.317 kDA

Genomic Context


Human

Location:	13q14.2
Sequence:	13; NC_000013.11 (47942656..48001273, complement)

Tissue Specificity

Widely expressed. Not expressed in liver and lung.

Subcellular Localizations

Mitochondrion.

Diseases

Mitochondrial Diseases
Mitochondrial Dna Depletion
Mitochondrial Encephalomyopathies
Dysmyelopoietic Syndromes
Acidosis
Muscle Hypotonia
Acidosis, Lactic
Methylmalonic Acidemia
Complete Hearing Loss
Leigh Disease
External Ophthalmoplegia
Ophthalmoplegia

Anemia
Inborn Errors Of Metabolism
Dystonia Disorders
Mitochondrial Myopathies
Chronic Progressive External Ophthalmoplegia
Sideroblastic Anemia

Interacting Proteins

ARL6IP1

Pathways

Oxidative Phosphorylation
Transport
Dna Replication
Electron Transport
Electron Transport Chain
Muscle Atrophy
Localization

Excretion

PTMs

Phosphorylation

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SUCLA2

References

PMID: 10727444 by Furuyama K., et al. Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is disrupted in sideroblastic anemia.

PMID: 9765291 by Johnson J.D., et al. Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes.