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- Table of Contents
SV2A Antibodies
AND SV2A ELISA kits, SV2A Proteins
Many biological assays use antibodies to detect SV2A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SV2A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SV2A antibodies...
Designing a Western blot for SV2A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SV2A Western Blot GuideDesigning an IHC experiment for SV2A? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SV2A IHC GuideSV2A Infographic by Boster Bio
All SV2A Products
Product
Figures
Specificity
Applications
Price
Anti-SV2A Antibody Picoband®
1 Citations
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # A03752-3
100 μg/vial
Cat # A03752-3
100 μg/vial
SV2A Overview
Facts about Synaptic vesicle glycoprotein 2A.
Synaptic vesicle glycoprotein 2A (SV2A)
Plays a role in the management of regulated secretion in endocrine and neural cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).
. .
Gene Information
| Human | |
|---|---|
| Gene Name: | SV2A |
| Uniprot: | Q7L0J3 |
| Entrez: | 9900 |
Family
| Belongs to: |
|---|
| major facilitator superfamily |
Alternative Names
KIAA0736; KIAA0736SV2; SV2; SV2A; synaptic vesicle glycoprotein 2A
Molecular Weight
Mass (kDA):
82.695 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q21.2 |
| Sequence: | 1; NC_000001.11 (149903318..149917844, complement) |
Subcellular Localizations
Cell junction, synapse, presynapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals.
Diseases
- Epilepsy
- Nervousness
- Neoplasms
- Pain
- Kindling, Neurologic
- Alzheimer's Disease
- Epilepsy, Generalized
- Neuralgia
- Convulsions
- Epilepsies, Partial
- Tetanus
- Malignant Neoplasms
Pathways
- Exocytosis
- Localization
- Transport
- Synaptic Transmission
- Innervation
- Secretion
- Synaptic Vesicle Exocytosis
- Endocytosis
- Glycosylation
- Aging
- Vesicle Fusion
- Clathrin-mediated Endocytosis
- Regeneration
PTMs
- Glycosylation
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SV2A
bosterbio.com/bosterbio-gene-info-cards/SV2A
References
PMID: 15210974 by Lynch B.A., et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam.
PMID: 29649119 by Gustafsson R., et al. Crystal structure of botulinum neurotoxin A2 in complex with the human protein receptor SV2C reveals plasticity in receptor binding.