SV2A Antibodies

AND SV2A ELISA kits, SV2A Proteins

Many biological assays use antibodies to detect SV2A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SV2A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SV2A antibodies...

We validate the specificity of these antibodies to SV2A by testing them on tissues known to express SV2A positively and negatively. Browse below to find the SV2A antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SV2A Infographic by Boster Bio

All SV2A Products

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Product

Figures

Specificity

Applications

Price

Anti-SV2A Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A03752
100ul

Anti-SV2A Antibody Picoband®

1 Citations

Western blot analysis of SV2A using anti-SV2A antibody (A03752-3)

IHC analysis of SV2A using anti-SV2A antibody (A03752-3)

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$370
Cat # A03752-3
100 μg/vial

SV2A (NM_014849) Human Over-expression Lysate

Human

$628
Cat # LS009900
20 µg, 100 µg

SV2A Overview

Facts about Synaptic vesicle glycoprotein 2A.

SV2A 3D structure. Source: alphafold

Synaptic vesicle glycoprotein 2A (SV2A)

Plays a role in the management of regulated secretion in endocrine and neural cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).

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Gene Information

Human
Gene Name:	SV2A
Uniprot:	Q7L0J3
Entrez:	9900

Family

Belongs to:

major facilitator superfamily

Alternative Names

KIAA0736; KIAA0736SV2; SV2; SV2A; synaptic vesicle glycoprotein 2A

Molecular Weight

Mass (kDA):
82.695 kDA

Genomic Context


Human

Location:	1q21.2
Sequence:	1; NC_000001.11 (149903318..149917844, complement)

Subcellular Localizations

Cell junction, synapse, presynapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals.

Diseases

Epilepsy
Nervousness
Neoplasms
Pain
Kindling, Neurologic
Alzheimer's Disease
Epilepsy, Generalized
Neuralgia
Convulsions
Epilepsies, Partial
Tetanus
Malignant Neoplasms

Paralysis Flaccid
Neuroblastoma
Absence Epilepsy
Varicosity
Epilepsy, Temporal Lobe
Epilepsies, Myoclonic

Pathways

Exocytosis
Localization
Transport
Synaptic Transmission
Innervation
Secretion
Synaptic Vesicle Exocytosis
Endocytosis
Glycosylation
Aging
Vesicle Fusion
Clathrin-mediated Endocytosis
Regeneration

Pathogenesis
Excretion
Translation
Cell Adhesion
Reflex
Cell Maturation
Swimming

PTMs

Glycosylation
Phosphorylation
Cleavage

Biotinylation
Formylation
Hydroxylation

Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SV2A

References

PMID: 15210974 by Lynch B.A., et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam.

PMID: 29649119 by Gustafsson R., et al. Crystal structure of botulinum neurotoxin A2 in complex with the human protein receptor SV2C reveals plasticity in receptor binding.