Tyrosine-protein kinase SYK (SYK)

Non-receptor tyrosine kinase that mediates signal transduction downstream of a variety of transmembrane receptors such as classical immunoreceptors such as the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular growth.

Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor may also be indirect and mediated by adapter proteins comprising ITAM or partial hemITAM domains.