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- Table of Contents
Shank3 Antibodies
AND Shank3 ELISA kits, Shank3 Proteins
Many biological assays use antibodies to detect Shank3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Shank3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Shank3 antibodies...
Designing a Western blot for Shank3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SHANK3 Western Blot GuideShank3 Infographic by Boster Bio
All Shank3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01231-1
100 μg/vial
Cat # A01231-1
100 μg/vial
Shank3 Overview
Facts about SH3 and multiple ankyrin repeat domains protein 3.
SH3 and multiple ankyrin repeat domains protein 3 (Shank3)
Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors through complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton.
Plays a role in the structural and functional organization of the dendritic spine and synaptic junction throughout the interaction with Arp2/3 and WAVE1 complex as well as the marketing of the F-actin clusters. Through this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Shank3 |
| Uniprot: | Q4ACU6 |
| Entrez: | 58234 |
Family
| Belongs to: |
|---|
| SHANK family |
Alternative Names
DEL22q13.3; KIAA1650proline rich synapse associated protein 2; Proline-rich synapse-associated protein 2; prosap2; PSAP2SH3 and multiple ankyrin repeat domains protein 3; SH3 and multiple ankyrin repeat domains 3; shank postsynaptic density protein; Shank3; SPANK-2
Molecular Weight
Mass (kDA):
185.397 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 15|15 E3 |
| Sequence: | 15; |
Tissue Specificity
In brain, highly expressed in striatum, thalamus, hippocampus and granule cells of the cerebellum.
Diseases
- Autistic Disorder
- Autism Spectrum Disorders
- 22q13.3 Deletion Syndrome
- Cytogenetic Abnormality
- Muscle Hypotonia
- Haploinsufficiency
- Developmental Delay (disorder)
- Developmental Disabilities
- Speech Delay
- Schizophrenia
- Tissue Adhesions
- Child Development Disorders, Pervasive
Pathways
- Synaptic Transmission
- Pathogenesis
- Cell Adhesion
- Localization
- Brain Development
- Methylation
- Dna Methylation
- Immune Response
- Translation
- Rna Interference
- Transport
- Synapse Maturation
- Synapse Organization
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Shank3
bosterbio.com/bosterbio-gene-info-cards/Shank3
References
PMID: 16606358 by Uchino S., et al. Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain- containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy- 5-methyl-4-isoxazole propionic acid receptor.
PMID: 24164323 by Waga C., et al. Identification of two novel Shank3 transcripts in the developing mouse neocortex.
1 Publications of Boster Shank3 Antibodies & ELISA Kits
- PubMed ID: 10.1007/s10571-016-0423-7, Expression of SHANK3 in the Temporal Neocortex of Patients with Intractable Temp...
*More publications can be found for each product on its corresponding product page