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- Table of Contents
Sirt6 Antibodies
AND Sirt6 ELISA kits, Sirt6 Proteins
Many biological assays use antibodies to detect Sirt6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sirt6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sirt6 antibodies...
Designing a Western blot for Sirt6? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SIRT6 Western Blot GuideSirt6 Infographic by Boster Bio
All Sirt6 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00611-3
100 μg/vial
Cat # A00611-3
100 μg/vial
Sirt6 Overview
Facts about NAD-dependent protein deacetylase sirtuin-6.
NAD-dependent protein deacetylase sirtuin-6 (Sirt6)
Modulates acetylation of histone H3 in telomeric chromatin throughout the S-phase of the cell cycle. Deacetylates histone H3K9Ac in NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes.
Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be needed for the institution of WRN with telomeres during S-phase and for normal telomere maintenance.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Sirt6 |
| Uniprot: | P59941 |
| Entrez: | 50721 |
Family
| Belongs to: |
|---|
| sirtuin family |
Alternative Names
EC 3.5.1.-; NAD-dependent deacetylase sirtuin-6; SIR2L6sir2-related protein type 6; SIR2-like protein 6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; sirtuin 6; sirtuin type 6
Molecular Weight
Mass (kDA):
36.92 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 10 C1|10 39.72 cM |
| Sequence: | 10; |
Tissue Specificity
Highest levels are found in muscle, thymus, spleen, brain and heart (at protein level).
Diseases
- Genomic Instability
- Malignant Neoplasms
- Inflammation
- Neoplasms
- Diabetes Mellitus
- Metabolic Diseases
- Abnormal Degeneration
- Premature Aging Syndrome
- Cardiovascular Diseases
- Obesity
- Hypertrophy
- Cell Transformation, Neoplastic
Pathways
- Aging
- Dna Repair
- Localization
- Gene Silencing
- Senescence
- Glycolysis
- Cellular Senescence
- Chromatin Silencing
- Secretion
- Glucose Homeostasis
- Histone Deacetylation
- Cell Cycle
- Fatty Acid Oxidation
PTMs
- Acetylation
- Deacetylation
- Oxidation
Research Areas
- Cancer
- Chromatin Research
- DNA Repair
- Epigenetics
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Sirt6
bosterbio.com/bosterbio-gene-info-cards/Sirt6
References
PMID: 15795229 by Liszt G., et al. Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase.
PMID: 16439206 by Mostoslavsky R., et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.
1 Publications of Boster Sirt6 Antibodies & ELISA Kits
- PubMed ID: 10.3389/fphar.2020.01150, Exogenous Hydrogen Sulfide Ameliorates Diabetic Myocardial Fibrosis by Inhibitin...
*More publications can be found for each product on its corresponding product page