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- Table of Contents
Zinc transporter 8 Antibodies
AND SLC30A8 ELISA kits, Zinc transporter 8 Proteins
Many biological assays use antibodies to detect Zinc transporter 8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc transporter 8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc transporter 8 antibodies...
Designing an IHC experiment for Zinc transporter 8? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SLC30A8 IHC GuideSLC30A8 Infographic by Boster Bio
All SLC30A8 Products
Product
Figures
Specificity
Applications
Price
Human
$628
Cat # LS169026
20 µg, 100 µg
Cat # LS169026
20 µg, 100 µg
SLC30A8 Overview
Facts about Zinc transporter 8.
Zinc transporter 8 (SLC30A8)
Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a significant component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells.
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Gene Information
| Human | |
|---|---|
| Gene Name: | SLC30A8 |
| Uniprot: | Q8IWU4 |
| Entrez: | 169026 |
Family
| Belongs to: |
|---|
| cation diffusion facilitator (CDF) transporter (TC 2.A.4) family |
Alternative Names
SLC30A8; solute carrier family 30 (zinc transporter), member 8; Solute carrier family 30 member 8; zinc transporter 8; zinc transporter ZnT-8; ZnT8; ZnT-8; ZNT8ZnT-8
Molecular Weight
Mass (kDA):
40.755 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q24.11 |
| Sequence: | 8; NC_000008.11 (116950217..117176714) |
Tissue Specificity
In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Associated with insulin and glucagon secretory granules.
Diseases
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Diabetes Mellitus, Insulin-dependent
- Autoimmunity
- Insulin Resistance
- Obesity
- Insulin Sensitivity
- Autoimmune Reaction
- Impaired Glucose Tolerance
- Hyperglycemia
- Cholangiocarcinoma
- Prediabetes Syndrome
Interacting Proteins
- CREB3L1
Pathways
- Secretion
- Insulin Secretion
- Pathogenesis
- Glucose Homeostasis
- Transport
- Insulin Processing
- Translation
- Glucagon Secretion
- Secretory Pathway
- Cell Development
- Localization
- Regeneration
- Stem Cell Differentiation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC30A8
bosterbio.com/bosterbio-gene-info-cards/SLC30A8
References
PMID: 15331542 by Chimienti F., et al. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules.
PMID: 16158222 by Chimienti F., et al. ZnT-8, a pancreatic beta-cell-specific zinc transporter.