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Zinc transporter ZIP14 Antibodies
AND SLC39A14 ELISA kits, Zinc transporter ZIP14 Proteins
Many biological assays use antibodies to detect Zinc transporter ZIP14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc transporter ZIP14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc transporter ZIP14 antibodies...
Designing a Western blot for Zinc transporter ZIP14? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SLC39A14 Western Blot GuideDesigning an IHC experiment for Zinc transporter ZIP14? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SLC39A14 IHC GuideSLC39A14 Infographic by Boster Bio
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SLC39A14 Overview
Facts about Zinc transporter ZIP14.
Zinc transporter ZIP14 (SLC39A14)
Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron.
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Gene Information
| Human | |
|---|---|
| Gene Name: | SLC39A14 |
| Uniprot: | Q15043 |
| Entrez: | 23516 |
Family
| Belongs to: |
|---|
| ZIP transporter (TC 2.A.5) family |
Alternative Names
Irt-like protein 14; LIV-1 subfamily of ZIP zinc transporter 4; LZT-Hs4; solute carrier family 39 (metal ion transporter), member 14; solute carrier family 39 (zinc transporter), member 14; solute carrier family 39 member 14; zinc transporter ZIP14; ZIP14; ZIP-14; zrt- and Irt-like protein 14
Molecular Weight
Mass (kDA):
54.212 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p21.3 |
| Sequence: | 8; NC_000008.11 (22367278..22434129) |
Tissue Specificity
Expressed in liver and in brain by large neurons in the globus pallidus, the insular cortex and the dentate nucleus and to a lower extent in the putamen and the caudate nucleus (at protein level) (PubMed:27231142). Isoform 1 is ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes (PubMed:15642354, PubMed:7584044, PubMed:27231142). Isoform 3 is widely expressed but not detected in brain, heart, skeletal muscle and fetal skin (PubMed:27231142).
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, lamellipodium. Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae.
Diseases
- Inflammation
- Malignant Neoplasms
- Hypozincaemia
- Neoplasms
- Hemochromatosis
- Colorectal Cancer
- Iron Overload
- Liver Carcinoma
- Liver Regeneration Disorder
- Disease Of Adrenal Medulla
- Neoplasm Metastasis
- Adenoma
Pathways
- Transport
- Localization
- Immune Response
- Liver Regeneration
- Receptor-mediated Endocytosis
- Endocytosis
- Regeneration
- Cytokine Production
- Cell Death
- Secretion
- Gluconeogenesis
- Hepatocyte Proliferation
- Glucose Homeostasis
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC39A14
bosterbio.com/bosterbio-gene-info-cards/SLC39A14
References
PMID: 12659941 by Taylor K.M., et al. The LZT proteins; the LIV-1 subfamily of zinc transporters.
PMID: 15642354 by Taylor K.M., et al. Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14.