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- Table of Contents
Syvn1 Antibodies
AND Syvn1 ELISA kits, Syvn1 Proteins
Many biological assays use antibodies to detect Syvn1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Syvn1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Syvn1 antibodies...
Designing an IHC experiment for Syvn1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SYVN1 IHC GuideSyvn1 Infographic by Boster Bio
All Syvn1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, IF, ICC, WB
$370
Cat # A02670-3
100 µg/vial
Cat # A02670-3
100 µg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02670
100 µl/vial
Cat # M02670
100 µl/vial
Syvn1 Overview
Facts about E3 ubiquitin-protein ligase synoviolin.
E3 ubiquitin-protein ligase synoviolin (Syvn1)
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin especially from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12975321, PubMed:15611074). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12975321, PubMed:15611074).
Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological role in transcription, cell cycle regulation and apoptosis (PubMed:17170702).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Syvn1 |
| Uniprot: | Q9DBY1 |
| Entrez: | 74126 |
Family
| Belongs to: |
|---|
| HRD1 family |
Alternative Names
E3 ubiquitin-protein ligase synoviolin; EC 6.3.2; HRD1EC 6.3.2.-; KIAA1810Synovial apoptosis inhibitor 1; MGC40372; synovial apoptosis inhibitor 1, synoviolin
Molecular Weight
Mass (kDA):
67.296 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 19|19 A |
| Sequence: | 19; |
Tissue Specificity
Ubiquitously expressed, with highest levels in bone, spleen, lung and testis. In the brain, present in neurons but not in glial cells. Up-regulated in synovial tissues from mice with collagen-induced arthritis (at protein level).
Diseases
- Rheumatoid Arthritis
- Arthritis
- Alzheimer's Disease
- Arthropathy
- Dislocations
- Endoplasmic Reticulum Stress
- Neoplasms
- Fibrosis
- Cystic Fibrosis
- Neurodegenerative Disorders
- Collagen Arthritis
- Carcinoma
Pathways
- Pathogenesis
- Transport
- Cell Death
- Protein Folding
- Conjugation
- Cell Cycle
- Cell Differentiation
- Rna Interference
- Secretion
- Regulation Of Cell Death
- Osteoclast Differentiation
- Secretory Pathway
- Transmembrane Transport
PTMs
- Ubiquitination
- Phosphorylation
Research Areas
- Apoptosis
- Cancer
- Cell Biology
- Ubiquitin Proteasome Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Syvn1
bosterbio.com/bosterbio-gene-info-cards/Syvn1
References
PMID: 12975321 by Amano T., et al. Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy.
PMID: 15519674 by Qi X., et al. Induction of murine HRD1 in experimental cerebral ischemia.