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- Table of Contents
TAOK2 Antibodies
AND TAOK2 ELISA kits, TAOK2 Proteins
Many biological assays use antibodies to detect TAOK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TAOK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TAOK2 antibodies...
Designing an IHC experiment for TAOK2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TAOK2 IHC GuideTAOK2 Infographic by Boster Bio
All TAOK2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A07466-1
100 μg/vial
Cat # A07466-1
100 μg/vial
Human, Mouse, Rat
IHC, WB
$370
Cat # P07063
100 μl/vial
Cat # P07063
100 μl/vial
TAOK2 Overview
Facts about Serine/threonine-protein kinase TAO2.
Serine/threonine-protein kinase TAO2 (TAOK2)
Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, triggered MAPK8, MAP2K3, MAP2K6 and tubulins.
Activates the MAPK14/p38 MAPK signaling pathway through the particular activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, such as cell contraction, membrane blebbing and apoptotic bodies formation.
Gene Information
| Human | |
|---|---|
| Gene Name: | TAOK2 |
| Uniprot: | Q9UL54 |
| Entrez: | 9344 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; KFC-C; KIAA0881PSK-1; Kinase from chicken homolog C; MAP3K17; MAP3K17PSK1-BETA; Prostate-derived STE20-like kinase 1; PSK1; PSK1EC 2.7.11.1; PSKhKFC-C; serine/threonine-protein kinase TAO2; TAO kinase 2; TAO1; TAO2; TAO2prostate derived STE20-like kinase PSK; TAOK2; Thousand and one amino acid protein 2; thousand and one amino acid protein kinase
Molecular Weight
Mass (kDA):
138.251 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p11.2 |
| Sequence: | 16; NC_000016.10 (29973868..29992261) |
Tissue Specificity
Ubiquitously expressed, with a higher level of expression in testis and brain.
Subcellular Localizations
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Nucleus. Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus.; [Isoform 2]: Cell projection, dendrite. In dendrites, colocalizes with PCDH8.
Diseases
- Child Development Disorders, Pervasive
- Autistic Disorder
- Autism Spectrum Disorders
Pathways
- Dendrite Morphogenesis
- Dendrite Development
PTMs
Research Areas
- Apoptosis
- Phospho-Specific
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TAOK2
bosterbio.com/bosterbio-gene-info-cards/TAOK2
References
PMID: 10660600 by Moore T.M., et al. PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the JNK MAPK pathway and regulates actin cytoskeletal organisation.
PMID: 13679851 by Yustein J.T., et al. Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.