Transcobalamin-2 Antibodies

AND TCN2 ELISA kits, Transcobalamin-2 Proteins

Many biological assays use antibodies to detect Transcobalamin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcobalamin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcobalamin-2 antibodies...

We validate the specificity of these antibodies to Transcobalamin-2 by testing them on tissues known to express TCN2 positively and negatively. Browse below to find the TCN2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TCN2 Infographic by Boster Bio

All TCN2 Products

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Product

Figures

Specificity

Applications

Price

Human TCN2/Transcobalamin-2 ELISA Kit PicoKine®

8 Q&As

Human

ELISA

$750
Cat # EK2038
96 wells/kit, with removable strips.

Anti-Transcobalamin-2 TCN2 Antibody

Western blot analysis of extracts of various cell lines, using TCN2 antibody at 1:1000 dilution

Human, Mouse

$405
Cat # A03819
100ul

Human TCN2/Transcobalamin-2 EZ-Set™ ELISA Kit (DIY Antibody Pairs)

Human

ELISA

$500
Cat # EZ2038
5 plates/kit

TCN2 Overview

Facts about Transcobalamin-2.

TCN2 3D structure. Source: alphafold

Transcobalamin-2 (TCN2)

Principal vitamin B12-binding and transport protein. Delivers cobalamin to cells.

Gene Information

Human
Gene Name:	TCN2
Uniprot:	P20062
Entrez:	6948

Family

Belongs to:

eukaryotic cobalamin transport proteins family

Alternative Names

D22S676; D22S750; macrocytic anemia; TC; TC-2; TC2II; TCII; TCN2; Transcobalamin II; transcobalamin II; macrocytic anemia; transcobalamin IITC II; transcobalamin-2; Vitamin B12-binding Protein 2

Molecular Weight

Mass (kDA):
47.535 kDA

Genomic Context


Human

Location:	22q12.2
Sequence:	22; NC_000022.11 (30607083..30627271)

Subcellular Localizations

Secreted.

Diseases

5,10-methylenetetrahydrofolate Reductase Deficiency
Congenital Abnormality
Vitamin B 12 Deficiency
Mastitis-metritis-agalactia Syndrome
Hyperhomocysteinemia
Cerebrovascular Accident
Intestinal Diseases
Malignant Neoplasms
Anemia
Cardiovascular Diseases
Congenital Omphalocele
Cleft Lip
Anemia, Megaloblastic

Cholangiocarcinoma
Pancytopenia
Congenital Exomphalos
Dysequilibrium Syndrome
Hereditary Diseases
Cleft Palate
Diabetes Mellitus

Pathways

Transport
Methylation
Dna Methylation
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Innate Immune Response
Transposition
Cellular Glucose Homeostasis
Response To Peptidoglycan
Brain Development
Aging
Immune Response
Tube Formation
Tumor Necrosis Factor Production

Cobalamin Transport
Virulence
Glucose Homeostasis
Positive Regulation Of Tumor Necrosis Factor Production
Interleukin-6 Production
Innate Immune Response
Vitamin Transport

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TCN2

References

PMID: 1708393 by Platica O., et al. The cDNA sequence and the deduced amino acid sequence of human transcobalamin II show homology with rat intrinsic factor and human transcobalamin I.

PMID: 8439564 by Li N., et al. Isolation and sequence analysis of variant forms of human transcobalamin II.