This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
TFRC Antibodies
AND TFRC ELISA kits, TFRC Proteins
Many biological assays use antibodies to detect TFRC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TFRC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TFRC antibodies...
Designing a Western blot for TFRC? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TFRC Western Blot GuideDesigning an IHC experiment for TFRC? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TFRC IHC GuideTFRC Infographic by Boster Bio
All TFRC Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # PB9233
100 μg/vial
Cat # PB9233
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IHC, WB
$370
Cat # M00591-1
100 μl
Cat # M00591-1
100 μl
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00591-3
100 μg
Cat # M00591-3
100 μg
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00591-4
20μL, 40μL, 100μL, 200μL
Cat # M00591-4
20μL, 40μL, 100μL, 200μL
Human, Mouse
ELISA
$540
Cat # EKC2231
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2231
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$480
Cat # EKC1102
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1102
1 kit, containing one 96-well plate and all necessary reagents
TFRC Overview
Facts about Transferrin receptor protein 1.
Transferrin receptor protein 1 (TFRC)
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release.
The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | TFRC |
| Uniprot: | P02786 |
| Entrez: | 7037 |
Family
| Belongs to: |
|---|
| peptidase M28 family |
Alternative Names
CD71 antigen; CD71; CD71TRFR; OX26 monoclonal; OX26 transferrin receptor; p90; T9; TfR (Transferrin R); TfR (TransferrinR); TfR; TFR1; TFRC; TR; transferrin receptor (p90, CD71); transferrin receptor protein 1; TRFR
Molecular Weight
Mass (kDA):
84.871 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q29 |
| Sequence: | 3; NC_000003.12 (196018694..196082123, complement) |
Subcellular Localizations
Cell membrane; Single-pass type II membrane protein. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.; [Transferrin receptor protein 1, serum form]: Secreted.
Diseases
- Malignant Neoplasms
- Neoplasms
- Iron Overload
- Anemia
- Hemochromatosis
- Carcinoma
- Hypoxia
- Iron Deficiency
- Schizophrenia
- Mammary Neoplasms
- Hereditary Hemochromatosis
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
Interacting Proteins
- ALB
- FTH1
- HFE
- SGTA
- SH3BP4
- TF
Pathways
- Transport
- Localization
- Pathogenesis
- Reverse Transcription
- Cell Proliferation
- Endocytosis
- Translation
- Osteoclast Differentiation
- Aging
- Cell Cycle
- Cell Development
- Osteoclast Development
- Cell Activation
PTMs
- Phosphorylation
- Acetylation
Research Areas
- Cell Biology
- Cellular Markers
- Hematopoietic Stem Cell Markers
- Immunology
- Signal Transduction
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TFRC
bosterbio.com/bosterbio-gene-info-cards/TFRC
References
PMID: 6090955 by Schneider C., et al. Primary structure of human transferrin receptor deduced from the mRNA sequence.
PMID: 6094009 by McClelland A., et al. The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence.
2 Publications of Boster TFRC Antibodies & ELISA Kits
- PubMed ID: 10.3892/or.2019.7189, Sulfasalazine‑induced ferroptosis in breast cancer cells is reduced by the inh...
- PubMed ID: 28008944, Amyloid precursor protein modulates Nav16 sodium channel currents through a Go-c...
*More publications can be found for each product on its corresponding product page