TIAM1 Antibodies

AND TIAM1 ELISA kits, TIAM1 Proteins

Many biological assays use antibodies to detect TIAM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TIAM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TIAM1 antibodies...

We validate the specificity of these antibodies to TIAM1 by testing them on tissues known to express TIAM1 positively and negatively. Browse below to find the TIAM1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for TIAM1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the TIAM1 Western Blot Guide

TIAM1 Infographic by Boster Bio

All TIAM1 Products

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Product

Figures

Specificity

Applications

Price

Anti-TIAM1 Antibody Picoband®

Western blot analysis of TIAM1 using anti-TIAM1 antibody (PB10103)

Human

$370
Cat # PB10103
100 μg/vial

TIAM1 (NM_003253) Human Over-expression Lysate

Human

$960
Cat # LS007074
20 µg, 100 µg

TIAM1 (NM_003253) Human Recombinant Protein

Coomassie blue staining of purified TIAM1 protein

$1858
Cat # PROTQ13009
20 µg

TIAM1 Overview

Facts about T-lymphoma invasion and metastasis-inducing protein 1.

TIAM1 3D structure. Source: alphafold

T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1)

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal actions. Acts as a GDP- dissociation stimulator protein which stimulates the GDP-GTP market activity of RHO-like GTPases and activates them.

Activates RAC1, CDC42, and to a lesser extent RHOA. Needed for normal cell adhesion and cell migration.

Gene Information

Human
Gene Name:	TIAM1
Uniprot:	Q13009
Entrez:	7074

Family

Belongs to:

TIAM family

Alternative Names

FLJ36302; human T-lymphoma invasion and metastasis inducing TIAM1 protein, 10TIAM-1; T-cell lymphoma invasion and metastasis 1; TIAM1; T-lymphoma invasion and metastasis-inducing protein 1

Molecular Weight

Mass (kDA):
177.508 kDA

Genomic Context


Human

Location:	21q22.11
Sequence:	21; NC_000021.9 (31118418..31559977, complement)

Tissue Specificity

Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

Subcellular Localizations

Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction.

Diseases

Cell Invasion
Neoplasms
Neoplasm Metastasis
Malignant Neoplasms
Tissue Adhesions
Carcinoma
Neoplasm Invasiveness
Lymphoma
Cell Transformation, Neoplastic
T-cell Lymphoma
Colorectal Cancer
Colorectal Neoplasms
Mammary Neoplasms

Malignant Neoplasm Of Breast
Metastatic Malignant Neoplasm To The Lymph Node
Lymphatic Metastasis
Tumor Progression
Adenocarcinoma
Malignant Paraganglionic Neoplasm
Neuroblastoma

Interacting Proteins

Ephb2
SDC1

Pathways

Cell Migration
Localization
Cell Adhesion
Cell Proliferation
Cell Growth
Cell Cycle
Rna Interference
Cell Motility
Secretion
Cell-cell Adhesion
Pathogenesis
Chemotaxis
Angiogenesis

Oncogenesis
Wound Healing
Endocytosis
Cytokinesis
Establishment Of Cell Polarity
S Phase
Tight Junction Assembly

PTMs

Phosphorylation
Cleavage
Prenylation

Reduction
Dephosphorylation
Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TIAM1

References

PMID: 7731688 by Habets G.G.M., et al. Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin.

PMID: 7753201 by Michiels F., et al. A role for Rac in Tiam1-induced membrane ruffling and invasion.